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• W3199591375 abstract "To investigate the likelihood of participation in genetic testing for hereditary cancer syndromes amongst infertility patients meeting National Comprehensive Cancer Network (NCCN) guidelines. A retrospective analysis of all female patients receiving genetic counseling for expanded carrier screening between April 2019 to December 2020 who met NCCN criteria for genetic testing. NCCN criteria screen for patients at risk of hereditable cancer based on personal and family history. We compared two populations of patients; infertility patients referred from a single infertility center and pregnant patients referred from their obstetrician. The primary outcome was the percentage of patients who declined the recommended cancer screening based on family or personal history. Further descriptive analysis was performed for the infertility population. Chi square analysis was used to compare the outcomes with a standard p < 0.05 as statistically significant. A total of 883 patients met inclusion criteria; 736 infertility patients and 147 pregnant patients. 640 (87%) of the female infertility patients declined the NCCN-recommended testing compared to 117 (79.6%) of the pregnant patients who declined testing (p < 0.01). The significant difference remained after adjusting for age. These results prompted further evaluation of the infertility population. Expanding the population to include both males and females, yielded 1,217 NCCN eligible patients receiving counseling with expanded carrier screening. Including male patients did not change the uptake in NCCN-recommended testing with 1,072 (87.9%) of patients declining testing. Demographics within this population revealed no difference in uptake based on age, gender, type of familial cancer history or ethnicity. Of the 145 patients who expressed interest in testing, only 53 (36.1% of those expressing interest) ultimately proceeded leaving just 4.4% of the NCCN eligible patients receiving the recommended testing. Women and patients over 40 were more likely to follow through with testing after expressing an interest. No other demographic differences were noted. Compared to the obstetric population, the reproductive medicine population appears less likely to be interested in obtaining genetic testing for hereditary cancer syndromes. Focused studies are needed to understand why this eligible group has such a high declination rate. The ability to test prior to pregnancy in the infertility population has the potential to reduce cancer risk in future offspring if PGTM is utilized. Better understanding of the factors that influence testing reluctance could assist in designing future care models to maximize the benefits of NCCN testing." @default.
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• W3199591375 date "2021-09-01" @default.
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• W3199591375 title "UPTAKE OF CANCER GENETIC TESTING IN THE INFERTILITY POPULATION MEETING NCCN CRITERIA" @default.
• W3199591375 doi "https://doi.org/10.1016/j.fertnstert.2021.07.157" @default.
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