FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199603721> ?p ?o ?g. }

• W3199603721 endingPage "289" @default.
• W3199603721 startingPage "279" @default.
• W3199603721 abstract "Germline variants might predict cancer progression. Bevacizumab improves overall survival (OS) in patients with advanced cancers. No biomarkers are available to identify patients that benefit from bevacizumab. A meta-analysis of genome-wide association studies (GWAS) was conducted in 1,520 patients from Phase III trials (CALGB 80303, 40503, 80405 and ICON7), where bevacizumab was randomized to treatment without bevacizumab. We aimed to identify genes and single nucleotide polymorphisms (SNPs) associated with survival independently of bevacizumab treatment or through interaction with bevacizumab. A cause-specific Cox model was used to test the SNP-OS association in both arms combined (prognostic), and the effect of SNPs-bevacizumab interaction on OS (predictive) in each study. The SNP effects across studies were combined using inverse variance. Findings were tested for replication in advanced colorectal and ovarian cancer patients from The Cancer Genome Atlas (TGCA). In the GWAS meta-analysis, patients with rs680949 in PRUNE2 experienced shorter OS compared to patients without it (P = 1.02 × 10-7 , hazard ratio [HR] = 1.57, 95% confidence interval [CI] 1.33-1.86), as well as in TCGA (P = .0219, HR = 1.58, 95% CI 1.07-2.35). In the GWAS meta-analysis, patients with rs16852804 in BARD1 experienced shorter OS compared to patients without it (P = 1.40 × 10-5 , HR = 1.51, 95% CI 1.25-1.82) as well as in TCGA (P = 1.39 × 10-4 , HR = 3.09, 95% CI 1.73-5.51). Patients with rs3795897 in AGAP1 experienced shorter OS in the bevacizumab arm compared to the nonbevacizumab arm (P = 1.43 × 10-5 ). The largest GWAS meta-analysis of bevacizumab treated patients identified PRUNE2 and BARD1 (tumor suppressor genes) as prognostic genes of colorectal and ovarian cancer, respectively, and AGAP1 as a potentially predictive gene that interacts with bevacizumab with respect to patient survival." @default.
• W3199603721 created "2021-09-27" @default.
• W3199603721 creator A5012221988 @default.
• W3199603721 creator A5017709484 @default.
• W3199603721 creator A5018244700 @default.
• W3199603721 creator A5022840912 @default.
• W3199603721 creator A5023531951 @default.
• W3199603721 creator A5031078301 @default.
• W3199603721 creator A5037875642 @default.
• W3199603721 creator A5043693232 @default.
• W3199603721 creator A5044565573 @default.
• W3199603721 creator A5045441776 @default.
• W3199603721 creator A5045774368 @default.
• W3199603721 creator A5061416108 @default.
• W3199603721 creator A5061620214 @default.
• W3199603721 creator A5065819570 @default.
• W3199603721 creator A5068268371 @default.
• W3199603721 creator A5069795948 @default.
• W3199603721 creator A5090156519 @default.
• W3199603721 date "2021-10-05" @default.
• W3199603721 modified "2023-10-17" @default.
• W3199603721 title "Genome‐wide association studies of survival in 1520 cancer patients treated with bevacizumab‐containing regimens" @default.
• W3199603721 cites W1499694647 @default.
• W3199603721 cites W1533942137 @default.
• W3199603721 cites W1783247684 @default.
• W3199603721 cites W1985339990 @default.
• W3199603721 cites W2013975692 @default.
• W3199603721 cites W2041515353 @default.
• W3199603721 cites W2081254854 @default.
• W3199603721 cites W2091842867 @default.
• W3199603721 cites W2097419174 @default.
• W3199603721 cites W2099271746 @default.
• W3199603721 cites W2106618350 @default.
• W3199603721 cites W2113122060 @default.
• W3199603721 cites W2117692326 @default.
• W3199603721 cites W2127385800 @default.
• W3199603721 cites W2128095147 @default.
• W3199603721 cites W2141820415 @default.
• W3199603721 cites W2149441684 @default.
• W3199603721 cites W2157752701 @default.
• W3199603721 cites W2158387167 @default.
• W3199603721 cites W2161577298 @default.
• W3199603721 cites W2166320441 @default.
• W3199603721 cites W2167869412 @default.
• W3199603721 cites W2169983032 @default.
• W3199603721 cites W2250481097 @default.
• W3199603721 cites W2346624277 @default.
• W3199603721 cites W2467321712 @default.
• W3199603721 cites W2712978371 @default.
• W3199603721 cites W2795989238 @default.
• W3199603721 cites W2796208126 @default.
• W3199603721 cites W2796408191 @default.
• W3199603721 cites W2804914389 @default.
• W3199603721 cites W2899407113 @default.
• W3199603721 cites W2901765988 @default.
• W3199603721 cites W2902159788 @default.
• W3199603721 cites W2921349646 @default.
• W3199603721 cites W3011051319 @default.
• W3199603721 cites W3036533886 @default.
• W3199603721 cites W3044161837 @default.
• W3199603721 cites W3047237191 @default.
• W3199603721 doi "https://doi.org/10.1002/ijc.33810" @default.
• W3199603721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8627468" @default.
• W3199603721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34528705" @default.
• W3199603721 hasPublicationYear "2021" @default.
• W3199603721 type Work @default.
• W3199603721 sameAs 3199603721 @default.
• W3199603721 citedByCount "7" @default.
• W3199603721 countsByYear W31996037212021 @default.
• W3199603721 countsByYear W31996037212022 @default.
• W3199603721 countsByYear W31996037212023 @default.
• W3199603721 crossrefType "journal-article" @default.
• W3199603721 hasAuthorship W3199603721A5012221988 @default.
• W3199603721 hasAuthorship W3199603721A5017709484 @default.
• W3199603721 hasAuthorship W3199603721A5018244700 @default.
• W3199603721 hasAuthorship W3199603721A5022840912 @default.
• W3199603721 hasAuthorship W3199603721A5023531951 @default.
• W3199603721 hasAuthorship W3199603721A5031078301 @default.
• W3199603721 hasAuthorship W3199603721A5037875642 @default.
• W3199603721 hasAuthorship W3199603721A5043693232 @default.
• W3199603721 hasAuthorship W3199603721A5044565573 @default.
• W3199603721 hasAuthorship W3199603721A5045441776 @default.
• W3199603721 hasAuthorship W3199603721A5045774368 @default.
• W3199603721 hasAuthorship W3199603721A5061416108 @default.
• W3199603721 hasAuthorship W3199603721A5061620214 @default.
• W3199603721 hasAuthorship W3199603721A5065819570 @default.
• W3199603721 hasAuthorship W3199603721A5068268371 @default.
• W3199603721 hasAuthorship W3199603721A5069795948 @default.
• W3199603721 hasAuthorship W3199603721A5090156519 @default.
• W3199603721 hasBestOaLocation W31996037211 @default.
• W3199603721 hasConcept C104317684 @default.
• W3199603721 hasConcept C106208931 @default.
• W3199603721 hasConcept C121608353 @default.
• W3199603721 hasConcept C126322002 @default.
• W3199603721 hasConcept C135763542 @default.
• W3199603721 hasConcept C139275648 @default.
• W3199603721 hasConcept C143998085 @default.
• W3199603721 hasConcept C153209595 @default.

• next