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• W3199626224 abstract "Abstract Drug resistance against coccidiosis has posed a significant threat to chicken welfare and productivity worldwide, putting daunting pressure on the poultry industry to reduce the use of chemoprophylactic drugs and live vaccines in poultry to treat intestinal diseases. Chicken coccidiosis, caused by an apicomplexan parasite of Eimeria spp., is a significant challenge worldwide. Due to the experience of economic loss in production and prevention of the disease, development of cost-effective vaccines or drugs that can stimulate defence against multiple Eimeria species is imperative to control coccidiosis. This study explored Eimeria immune mapped protein-1 (IMP-1) to develop a multiepitope-based vaccine against coccidiosis by identifying antigenic T-cell and B-cell epitope candidates through immunoinformatic techniques. This resulted in the design of 7 CD8 + , 21 CD4 + T-cell epitopes and 6 B-cell epitopes, connected using AAY, GPGPG and KK linkers to form a vaccine construct. A Cholera Toxin B (CTB) adjuvant was attached to the N-terminal of the multiepitope construct to improve the immunogenicity of the vaccine. The designed vaccine was assessed for immunogenicity (8.59968), allergenicity and physiochemical parameters, which revealed the construct molecular weight of 73.25 kDa, theoretical pI of 8.23 and instability index of 33.40. Molecular docking simulation of vaccine with TLR-5 with binding affinity of − 151.893 kcal/mol revealed good structural interaction and stability of protein structure of vaccine construct. The designed vaccine predicts the induction of immunity and boosted host's immune system through production of antibodies and cytokines, vital in hindering surface entry of parasites into host. This is a very important step in vaccine development though further experimental study is still required to validate these results." @default.
• W3199626224 created "2021-09-27" @default.
• W3199626224 creator A5019088441 @default.
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• W3199626224 date "2021-09-14" @default.
• W3199626224 modified "2023-10-15" @default.
• W3199626224 title "Designing multiepitope-based vaccine against Eimeria from immune mapped protein 1 (IMP-1) antigen using immunoinformatic approach" @default.
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• W3199626224 doi "https://doi.org/10.1038/s41598-021-97880-6" @default.
• W3199626224 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8440781" @default.
• W3199626224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34521964" @default.
• W3199626224 hasPublicationYear "2021" @default.
• W3199626224 type Work @default.
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• W3199626224 hasAuthorship W3199626224A5019088441 @default.
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• W3199626224 hasAuthorship W3199626224A5060288467 @default.
• W3199626224 hasAuthorship W3199626224A5074091602 @default.

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