FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199636281> ?p ?o ?g. }

• W3199636281 endingPage "136251" @default.
• W3199636281 startingPage "136251" @default.
• W3199636281 abstract "Parkinson's disease (PD) is a neurodegenerative disease caused by the death of dopaminergic neurons in the substantia nigra pars compacta (SNpc), characterized by motor dysfunction. While PD symptoms are well treated with L-DOPA, continuous use can cause L-DOPA-induced dyskinesia (LID). We have previously demonstrated that sub-anesthetic ketamine attenuated LID development in rodents, measured by abnormal involuntary movements (AIMs), and reduced the density of maladaptive striatal dendritic mushroom spines. Microglia may play a role by phagocytosing maladaptive neuronal spines. In this exploratory study, we hypothesized that ketamine would prevent AIMs and change microglia ramified morphology - an indicator of a microglia response. Unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rats were primed with daily injections of L-DOPA for 14 days, treated on days 0 and 7 for 10-hours with sub-anesthetic ketamine (i.p.), and we replicated that this attenuated LID development. We further extended our prior work by showing that while ketamine treatment did lead to an increase of striatal interleukin-6 in dyskinetic rats, indicating a modulation of an inflammatory response, it did not change microglia number or morphology in the dyskinetic striatum. Yet an increase of CD68 in the SNpc of 6-OHDA-lesioned hemispheres post-ketamine indicates increased microglia phagocytosis suggestive of a lingering microglial response to 6-OHDA injury in the SNpc pointing to possible anti-inflammatory action in the PD model in addition to anti-dyskinetic action. In conclusion, we provide further support for sub-anesthetic ketamine treatment of LID. The mechanisms of action for ketamine, specifically related to inflammation and microglia phagocytic functions, are emerging, and require further examination." @default.
• W3199636281 created "2021-09-27" @default.
• W3199636281 creator A5041020554 @default.
• W3199636281 creator A5042609697 @default.
• W3199636281 creator A5060086714 @default.
• W3199636281 creator A5065766833 @default.
• W3199636281 creator A5091535892 @default.
• W3199636281 date "2021-11-01" @default.
• W3199636281 modified "2023-10-14" @default.
• W3199636281 title "Evaluation of microglia in a rodent model of Parkinson’s disease primed with L-DOPA after sub-anesthetic ketamine treatment" @default.
• W3199636281 cites W1780973376 @default.
• W3199636281 cites W1977553663 @default.
• W3199636281 cites W1982982528 @default.
• W3199636281 cites W1986017124 @default.
• W3199636281 cites W1995094023 @default.
• W3199636281 cites W2014583561 @default.
• W3199636281 cites W2023942502 @default.
• W3199636281 cites W2027021810 @default.
• W3199636281 cites W2031649295 @default.
• W3199636281 cites W2093256000 @default.
• W3199636281 cites W2112111711 @default.
• W3199636281 cites W2131016140 @default.
• W3199636281 cites W2173305081 @default.
• W3199636281 cites W2277614354 @default.
• W3199636281 cites W2418868559 @default.
• W3199636281 cites W2529082504 @default.
• W3199636281 cites W2529277525 @default.
• W3199636281 cites W2557933310 @default.
• W3199636281 cites W2725043130 @default.
• W3199636281 cites W2754967293 @default.
• W3199636281 cites W2762601381 @default.
• W3199636281 cites W2790275773 @default.
• W3199636281 cites W2806300791 @default.
• W3199636281 cites W2947681879 @default.
• W3199636281 cites W2969499475 @default.
• W3199636281 cites W2984808385 @default.
• W3199636281 cites W3044619577 @default.
• W3199636281 cites W3047983481 @default.
• W3199636281 cites W3085943025 @default.
• W3199636281 cites W3135631261 @default.
• W3199636281 cites W4239908405 @default.
• W3199636281 doi "https://doi.org/10.1016/j.neulet.2021.136251" @default.
• W3199636281 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8638748" @default.
• W3199636281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34536508" @default.
• W3199636281 hasPublicationYear "2021" @default.
• W3199636281 type Work @default.
• W3199636281 sameAs 3199636281 @default.
• W3199636281 citedByCount "1" @default.
• W3199636281 crossrefType "journal-article" @default.
• W3199636281 hasAuthorship W3199636281A5041020554 @default.
• W3199636281 hasAuthorship W3199636281A5042609697 @default.
• W3199636281 hasAuthorship W3199636281A5060086714 @default.
• W3199636281 hasAuthorship W3199636281A5065766833 @default.
• W3199636281 hasAuthorship W3199636281A5091535892 @default.
• W3199636281 hasBestOaLocation W31996362812 @default.
• W3199636281 hasConcept C126322002 @default.
• W3199636281 hasConcept C137183658 @default.
• W3199636281 hasConcept C15744967 @default.
• W3199636281 hasConcept C169760540 @default.
• W3199636281 hasConcept C2776773494 @default.
• W3199636281 hasConcept C2776914184 @default.
• W3199636281 hasConcept C2778162923 @default.
• W3199636281 hasConcept C2779134260 @default.
• W3199636281 hasConcept C2779734285 @default.
• W3199636281 hasConcept C2779830541 @default.
• W3199636281 hasConcept C2780062018 @default.
• W3199636281 hasConcept C2780795376 @default.
• W3199636281 hasConcept C2780938664 @default.
• W3199636281 hasConcept C42219234 @default.
• W3199636281 hasConcept C513476851 @default.
• W3199636281 hasConcept C71924100 @default.
• W3199636281 hasConcept C98274493 @default.
• W3199636281 hasConceptScore W3199636281C126322002 @default.
• W3199636281 hasConceptScore W3199636281C137183658 @default.
• W3199636281 hasConceptScore W3199636281C15744967 @default.
• W3199636281 hasConceptScore W3199636281C169760540 @default.
• W3199636281 hasConceptScore W3199636281C2776773494 @default.
• W3199636281 hasConceptScore W3199636281C2776914184 @default.
• W3199636281 hasConceptScore W3199636281C2778162923 @default.
• W3199636281 hasConceptScore W3199636281C2779134260 @default.
• W3199636281 hasConceptScore W3199636281C2779734285 @default.
• W3199636281 hasConceptScore W3199636281C2779830541 @default.
• W3199636281 hasConceptScore W3199636281C2780062018 @default.
• W3199636281 hasConceptScore W3199636281C2780795376 @default.
• W3199636281 hasConceptScore W3199636281C2780938664 @default.
• W3199636281 hasConceptScore W3199636281C42219234 @default.
• W3199636281 hasConceptScore W3199636281C513476851 @default.
• W3199636281 hasConceptScore W3199636281C71924100 @default.
• W3199636281 hasConceptScore W3199636281C98274493 @default.
• W3199636281 hasFunder F4320306080 @default.
• W3199636281 hasFunder F4320332140 @default.
• W3199636281 hasLocation W31996362811 @default.
• W3199636281 hasLocation W31996362812 @default.
• W3199636281 hasLocation W31996362813 @default.
• W3199636281 hasOpenAccess W3199636281 @default.
• W3199636281 hasPrimaryLocation W31996362811 @default.
• W3199636281 hasRelatedWork W1589264845 @default.
• W3199636281 hasRelatedWork W178985012 @default.

• next