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- W3199643124 abstract "So-called ρ0 cells lack mitochondrial DNA and are therefore incapable of aerobic ATP synthesis. How cells adapt to survive ablation of oxidative phosphorylation remains poorly understood. Complexome profiling analysis of ρ0 cells covered 1,002 mitochondrial proteins and revealed changes in abundance and organization of numerous multiprotein complexes including previously not described assemblies. Beyond multiple subassemblies of complexes that would normally contain components encoded by mitochondrial DNA, we observed widespread reorganization of the complexome. This included distinct changes in the expression pattern of adenine nucleotide carrier isoforms, other mitochondrial transporters, and components of the protein import machinery. Remarkably, ablation of mitochondrial DNA hardly affected the complexes organizing cristae junctions indicating that the altered cristae morphology in ρ0 mitochondria predominantly resulted from the loss of complex V dimers required to impose narrow curvatures to the inner membrane. Our data provide a comprehensive resource for in-depth analysis of remodeling of the mitochondrial complexome in response to respiratory deficiency." @default.
- W3199643124 created "2021-09-27" @default.
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- W3199643124 date "2021-09-20" @default.
- W3199643124 modified "2023-10-17" @default.
- W3199643124 title "Ablation of mitochondrial DNA results in widespread remodeling of the mitochondrial complexome" @default.
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- W3199643124 cites W1982896986 @default.
- W3199643124 cites W1988478272 @default.
- W3199643124 cites W1991076291 @default.
- W3199643124 cites W1993490757 @default.
- W3199643124 cites W2003717466 @default.
- W3199643124 cites W2006035995 @default.
- W3199643124 cites W2011135370 @default.
- W3199643124 cites W2012971149 @default.
- W3199643124 cites W2013716694 @default.
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- W3199643124 cites W2028159245 @default.
- W3199643124 cites W2035046899 @default.
- W3199643124 cites W2037464535 @default.
- W3199643124 cites W2039413161 @default.
- W3199643124 cites W2046987125 @default.
- W3199643124 cites W2051649959 @default.
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- W3199643124 cites W2059453827 @default.
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- W3199643124 cites W2072238534 @default.
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- W3199643124 cites W2145723200 @default.
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- W3199643124 doi "https://doi.org/10.15252/embj.2021108648" @default.
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