FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199695230> ?p ?o ?g. }

• W3199695230 endingPage "249" @default.
• W3199695230 startingPage "238" @default.
• W3199695230 abstract "This review focuses on asparaginase, a key component of childhood acute lymphoblastic leukaemia (ALL) treatment since the 1970s. This review evaluates how much asparaginase is needed for optimal outcome in childhood ALL. We provide an overview of asparaginase dose intensity, i.e. duration of total cumulative exposure in weeks and level of exposure reflected by dose and/or asparaginase activity level, and the corresponding outcome. We systematically searched papers published between January 1990 and March 2021 in the PubMed and MEDLINE databases and included 20 papers. The level and duration of exposure were based on the pharmacokinetic profile of the drug and the assumption that trough asparaginase activity levels of ≥100 IU/L should be achieved for complete l-asparagine depletion. The statistical meta-analysis of outcomes was not performed because different outcome measures were used. The level of exposure was not associated with the outcome as long as therapeutic asparaginase activity levels of ≥100 IU/L were reached. Conflicting results were found in the randomised controlled trials, but all truncation studies showed that the duration of exposure (expressed as weeks of l-asparagine depletion) does affect the outcome; however, no clear cutoff for optimal exposure duration was determined. Optimal exposure duration will also depend on immunophenotype, (cyto)genetic subgroups, risk group stratification and backbone therapy." @default.
• W3199695230 created "2021-09-27" @default.
• W3199695230 creator A5017731507 @default.
• W3199695230 creator A5035292815 @default.
• W3199695230 creator A5062936339 @default.
• W3199695230 date "2021-11-01" @default.
• W3199695230 modified "2023-10-11" @default.
• W3199695230 title "How much asparaginase is needed for optimal outcome in childhood acute lymphoblastic leukaemia? A systematic review" @default.
• W3199695230 cites W1851696426 @default.
• W3199695230 cites W1925862729 @default.
• W3199695230 cites W1966763079 @default.
• W3199695230 cites W1984924924 @default.
• W3199695230 cites W1998762015 @default.
• W3199695230 cites W2002567197 @default.
• W3199695230 cites W2004157598 @default.
• W3199695230 cites W2004836077 @default.
• W3199695230 cites W2005688611 @default.
• W3199695230 cites W2013649602 @default.
• W3199695230 cites W2017265604 @default.
• W3199695230 cites W2026940058 @default.
• W3199695230 cites W2035309334 @default.
• W3199695230 cites W2050766351 @default.
• W3199695230 cites W2068619849 @default.
• W3199695230 cites W2069643559 @default.
• W3199695230 cites W2069709802 @default.
• W3199695230 cites W2080828049 @default.
• W3199695230 cites W2086155728 @default.
• W3199695230 cites W2102072644 @default.
• W3199695230 cites W2103347449 @default.
• W3199695230 cites W2103963325 @default.
• W3199695230 cites W2113477288 @default.
• W3199695230 cites W2117623554 @default.
• W3199695230 cites W2127153931 @default.
• W3199695230 cites W2140819149 @default.
• W3199695230 cites W2144921015 @default.
• W3199695230 cites W2146375276 @default.
• W3199695230 cites W2148631711 @default.
• W3199695230 cites W2149324701 @default.
• W3199695230 cites W2154174652 @default.
• W3199695230 cites W2156840245 @default.
• W3199695230 cites W2169732420 @default.
• W3199695230 cites W2292251821 @default.
• W3199695230 cites W2321589388 @default.
• W3199695230 cites W2333196452 @default.
• W3199695230 cites W2413038045 @default.
• W3199695230 cites W2554250866 @default.
• W3199695230 cites W2727803568 @default.
• W3199695230 cites W2740228493 @default.
• W3199695230 cites W2769895972 @default.
• W3199695230 cites W2800788397 @default.
• W3199695230 cites W2913445113 @default.
• W3199695230 cites W2913580720 @default.
• W3199695230 cites W2921451716 @default.
• W3199695230 cites W2939150686 @default.
• W3199695230 cites W2982248350 @default.
• W3199695230 cites W3000547742 @default.
• W3199695230 cites W3015698333 @default.
• W3199695230 cites W3023012710 @default.
• W3199695230 cites W3075043380 @default.
• W3199695230 cites W3089122708 @default.
• W3199695230 cites W3137758248 @default.
• W3199695230 cites W4229728954 @default.
• W3199695230 doi "https://doi.org/10.1016/j.ejca.2021.08.025" @default.
• W3199695230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34536947" @default.
• W3199695230 hasPublicationYear "2021" @default.
• W3199695230 type Work @default.
• W3199695230 sameAs 3199695230 @default.
• W3199695230 citedByCount "11" @default.
• W3199695230 countsByYear W31996952302022 @default.
• W3199695230 countsByYear W31996952302023 @default.
• W3199695230 crossrefType "journal-article" @default.
• W3199695230 hasAuthorship W3199695230A5017731507 @default.
• W3199695230 hasAuthorship W3199695230A5035292815 @default.
• W3199695230 hasAuthorship W3199695230A5062936339 @default.
• W3199695230 hasConcept C126322002 @default.
• W3199695230 hasConcept C143998085 @default.
• W3199695230 hasConcept C187212893 @default.
• W3199695230 hasConcept C2778461978 @default.
• W3199695230 hasConcept C2778904437 @default.
• W3199695230 hasConcept C2909962599 @default.
• W3199695230 hasConcept C71924100 @default.
• W3199695230 hasConceptScore W3199695230C126322002 @default.
• W3199695230 hasConceptScore W3199695230C143998085 @default.
• W3199695230 hasConceptScore W3199695230C187212893 @default.
• W3199695230 hasConceptScore W3199695230C2778461978 @default.
• W3199695230 hasConceptScore W3199695230C2778904437 @default.
• W3199695230 hasConceptScore W3199695230C2909962599 @default.
• W3199695230 hasConceptScore W3199695230C71924100 @default.
• W3199695230 hasLocation W31996952301 @default.
• W3199695230 hasLocation W31996952302 @default.
• W3199695230 hasOpenAccess W3199695230 @default.
• W3199695230 hasPrimaryLocation W31996952301 @default.
• W3199695230 hasRelatedWork W1506200166 @default.
• W3199695230 hasRelatedWork W1995515455 @default.
• W3199695230 hasRelatedWork W2048182022 @default.
• W3199695230 hasRelatedWork W2080531066 @default.
• W3199695230 hasRelatedWork W2604872355 @default.
• W3199695230 hasRelatedWork W2748952813 @default.

• next