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• W3199695919 endingPage "118424" @default.
• W3199695919 startingPage "118424" @default.
• W3199695919 abstract "The green fluorescent protein (GFP) chromophore has been widely applied as a biological marker or viscosity sensor. However, modulation of GFP chromophore for photodynamic therapy (PDT) has rarely been reported. Inspired by this, through the unique phenothiazine-anchored strategy, a near-infrared emission photosensitizer Lys-PtzFP was designed and synthesized to achieve this process. The maximum absorption wavelength of Lys-PtzFP was 460 nm and the corresponding molar extinction coefficient was 6.60 × 10 4 M −1 cm −1 in MeOH. The maximum emission wavelengths of Lys-PtzFP was at 725 nm. The photosensitizer Lys-PtzFP showed a high singlet oxygen quantum yield (Φ Δ = 0.42) and low fluorescence quantum yield (φ F = 0.002) in MeOH. Besides, Lys-PtzFP possessed high specificity for lysosomes with negligible dark cytotoxicity (MTT assay >94.6%), good photostability and low half-maximal inhibitory concentration (IC 50 ) of 0.93 μM. Finally, the intracellular photodynamic therapy experiments revealed that Lys-PtzFP can produce singlet oxygen in lysosomes and induce apoptosis under irradiation. In conclusion, Lys-PtzFP could be a promising photosensitizer for PDT and two-photon imaging applications. This type of photosensitizer can inspire the development of new photosensitizers for further explore highly efficient PDT. • Heavy atom-free photosensitizer, Φ Δ = 0.42, IC 50 = 0.93 μM. • Phenothiazine-GFP chromophore with near-Infrared emission of 725 nm. • Two-photon fluorescent imaging." @default.
• W3199695919 created "2021-09-27" @default.
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• W3199695919 date "2021-12-01" @default.
• W3199695919 modified "2023-10-18" @default.
• W3199695919 title "Modulation of fluorescent protein chromophore for photodynamic therapy and two-photon fluorescent imaging in living cells" @default.
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• W3199695919 doi "https://doi.org/10.1016/j.jlumin.2021.118424" @default.
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