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- W3199720305 abstract "TRPV1 is a polymodal receptor ion channel that is best known to function as a molecular thermometer. It is activated in diverse ways, including by heat, protons (low pH), and vanilloid compounds, such as capsaicin. In this review, we summarize molecular studies of TRPV1 thermosensing, focusing on the cross-talk between heat and other activation modes. Additional insights from TRPV1 isoforms and non-rodent/non-human TRPV1 ortholog studies are also discussed in this context. While the molecular mechanism of heat activation is still emerging, it is clear that TRPV1 thermosensing is modulated allosterically, i.e., at a distance, with contributions from many distinct regions of the channel. Similarly, current studies identify cross-talk between heat and other TRPV1 activation modes, such as protons and capsaicin, and that these modes can generally be selectively disentangled. In aggregate, this suggests that future TRPV1 molecular studies should define allosteric pathways and provide mechanistic insight, thereby enabling mode-selective manipulation of the polymodal receptor. These advances are anticipated to have significant implications in both basic and applied biomedical sciences." @default.
- W3199720305 created "2021-09-27" @default.
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- W3199720305 creator A5038180900 @default.
- W3199720305 creator A5046952556 @default.
- W3199720305 date "2021-10-26" @default.
- W3199720305 modified "2023-09-23" @default.
- W3199720305 title "A molecular perspective on identifying TRPV1 thermosensitive regions and disentangling polymodal activation" @default.
- W3199720305 cites W1480787916 @default.
- W3199720305 cites W1492591187 @default.
- W3199720305 cites W1511198581 @default.
- W3199720305 cites W1515343767 @default.
- W3199720305 cites W1536598425 @default.
- W3199720305 cites W1554239893 @default.
- W3199720305 cites W1568124021 @default.
- W3199720305 cites W1586769170 @default.
- W3199720305 cites W1605831964 @default.
- W3199720305 cites W1790023182 @default.
- W3199720305 cites W1865060404 @default.
- W3199720305 cites W1890090833 @default.
- W3199720305 cites W1896407318 @default.
- W3199720305 cites W1959838017 @default.
- W3199720305 cites W1964302331 @default.
- W3199720305 cites W1965371907 @default.
- W3199720305 cites W1965425684 @default.
- W3199720305 cites W1965985711 @default.
- W3199720305 cites W1968495593 @default.
- W3199720305 cites W1971566600 @default.
- W3199720305 cites W1971754431 @default.
- W3199720305 cites W1973796039 @default.
- W3199720305 cites W197405432 @default.
- W3199720305 cites W1974641725 @default.
- W3199720305 cites W1976236772 @default.
- W3199720305 cites W1977041882 @default.
- W3199720305 cites W1979903970 @default.
- W3199720305 cites W1981494335 @default.
- W3199720305 cites W1981659462 @default.
- W3199720305 cites W1983377357 @default.
- W3199720305 cites W1985030046 @default.
- W3199720305 cites W1986385165 @default.
- W3199720305 cites W1988174555 @default.
- W3199720305 cites W1988375390 @default.
- W3199720305 cites W1990769918 @default.
- W3199720305 cites W1991734376 @default.
- W3199720305 cites W1994849388 @default.
- W3199720305 cites W1995683486 @default.
- W3199720305 cites W1996706321 @default.
- W3199720305 cites W1998093640 @default.
- W3199720305 cites W1998425702 @default.
- W3199720305 cites W2001294652 @default.
- W3199720305 cites W2002594079 @default.
- W3199720305 cites W2007034094 @default.
- W3199720305 cites W2007082466 @default.
- W3199720305 cites W2008522439 @default.
- W3199720305 cites W2009294684 @default.
- W3199720305 cites W2011295158 @default.
- W3199720305 cites W2011920499 @default.
- W3199720305 cites W2014389293 @default.
- W3199720305 cites W2016883170 @default.
- W3199720305 cites W2018401454 @default.
- W3199720305 cites W2018608365 @default.
- W3199720305 cites W2020164437 @default.
- W3199720305 cites W2024984063 @default.
- W3199720305 cites W2026361606 @default.
- W3199720305 cites W2029360579 @default.
- W3199720305 cites W2030047746 @default.
- W3199720305 cites W2031952894 @default.
- W3199720305 cites W2033457590 @default.
- W3199720305 cites W2037651260 @default.
- W3199720305 cites W2039263844 @default.
- W3199720305 cites W2039908720 @default.
- W3199720305 cites W2042133456 @default.
- W3199720305 cites W2042451060 @default.
- W3199720305 cites W2042968117 @default.
- W3199720305 cites W2044888394 @default.
- W3199720305 cites W2047169541 @default.
- W3199720305 cites W2050781058 @default.
- W3199720305 cites W2050957868 @default.
- W3199720305 cites W2052870492 @default.
- W3199720305 cites W2058970301 @default.
- W3199720305 cites W2059636104 @default.
- W3199720305 cites W2062776570 @default.
- W3199720305 cites W2063819137 @default.
- W3199720305 cites W2064333263 @default.
- W3199720305 cites W2065687666 @default.
- W3199720305 cites W2066098715 @default.
- W3199720305 cites W2067734788 @default.
- W3199720305 cites W2072644682 @default.
- W3199720305 cites W2073071064 @default.
- W3199720305 cites W2074252493 @default.
- W3199720305 cites W2079100054 @default.
- W3199720305 cites W2082179247 @default.
- W3199720305 cites W2082708562 @default.
- W3199720305 cites W2083484726 @default.
- W3199720305 cites W2088351328 @default.
- W3199720305 cites W2088764206 @default.
- W3199720305 cites W2090617423 @default.