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- W3199722013 abstract "The incidence of atopic dermatitis (AD), a disease characterized by an abnormal immune balance and skin barrier function, has increased rapidly in developed countries. This study investigated the anti-atopic effect of Lithospermum erythrorhizon (LE) using NC/Nga mice induced by 2,4-dinitrochlorobenzene. LE reduced AD clinical symptoms, including inflammatory cell infiltration, epidermal thickness, ear thickness, and scratching behavior, in the mice. Additionally, LE reduced serum IgE and histamine levels, and restored the T helper (Th) 1/Th2 immune balance through regulation of the IgG1/IgG2a ratio. LE also reduced the levels of AD-related cytokines and chemokines, including interleukin (IL)-1β, IL-4, IL-6, tumor necrosis factor-α (TNF-α), thymic stromal lymphopoietin, thymus and activation-regulated chemokine, macrophage-derived chemokine, regulated on activation, normal T cell expressed and secreted, and monocyte chemoattractant protein-1 in the serum. Moreover, LE modulated AD-related cytokines and chemokines expressed and secreted by Th1, Th2, Th17, and Th22 cells in the dorsal skin and splenocytes. Furthermore, LE restored skin barrier function by increasing pro-filaggrin gene expression and levels of skin barrier-related proteins filaggrin, involucrin, loricrin, occludin, and zonula occludens-1. These results suggest that LE is a potential therapeutic agent that can alleviate AD by modulating Th1/Th2 immune balance and restoring skin barrier function." @default.
- W3199722013 created "2021-09-27" @default.
- W3199722013 creator A5015164764 @default.
- W3199722013 creator A5021865123 @default.
- W3199722013 creator A5055267059 @default.
- W3199722013 date "2021-09-15" @default.
- W3199722013 modified "2023-09-26" @default.
- W3199722013 title "Lithospermum erythrorhizon Alleviates Atopic Dermatitis-like Skin Lesions by Restoring Immune Balance and Skin Barrier Function in 2.4-Dinitrochlorobenzene-Induced NC/Nga Mice" @default.
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- W3199722013 doi "https://doi.org/10.3390/nu13093209" @default.
- W3199722013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8470668" @default.
- W3199722013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34579088" @default.
- W3199722013 hasPublicationYear "2021" @default.
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