Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199749872> ?p ?o ?g. }
- W3199749872 endingPage "219" @default.
- W3199749872 startingPage "208" @default.
- W3199749872 abstract "Gene therapy has gained popularity in the treatment of incurable diseases. However, cell components, such as surface membrane, cytoskeleton protein, and nuclear envelope, retard the transport of nucleic acids, lowering the transfection efficiency. We developed a physical-chemical hybrid platform (S-RCLs) involving cationic lipid nanoparticles (RCLs) exposed to cyclic stretch. The transfection efficiency and delivery mechanisms of S-RCLs for siRNAs and pDNAs (plasmid DNAs encoding luciferase) were investigated. S-RCLs effectively delivered both siRNAs and pDNAs by overcoming the cell barriers. Mechanistically, S-RCLs promote the cellular uptake mediated by CD44, EH-domain containing 2 (EHD2), and caveolin-1 (CAV-1); intracellular transport via MAP6 Domain Containing 1 (Map6d1) and F-actin; and DNA transcription regulated by LSM3 and Hist1h3e in the nucleus. Thus, S-RCLs are a promising hybrid platform with excellent efficiency and biocompatibility for gene delivery both in vitro and in vivo." @default.
- W3199749872 created "2021-09-27" @default.
- W3199749872 creator A5020902504 @default.
- W3199749872 creator A5044083323 @default.
- W3199749872 creator A5055685732 @default.
- W3199749872 creator A5056636389 @default.
- W3199749872 creator A5077178717 @default.
- W3199749872 creator A5078188641 @default.
- W3199749872 date "2021-11-01" @default.
- W3199749872 modified "2023-09-24" @default.
- W3199749872 title "Mechanical stretching of cells and lipid nanoparticles for nucleic acid delivery" @default.
- W3199749872 cites W1529713622 @default.
- W3199749872 cites W1569657295 @default.
- W3199749872 cites W1821834469 @default.
- W3199749872 cites W1874432494 @default.
- W3199749872 cites W1989477774 @default.
- W3199749872 cites W1991111898 @default.
- W3199749872 cites W1994233268 @default.
- W3199749872 cites W1998450603 @default.
- W3199749872 cites W1998655416 @default.
- W3199749872 cites W1998963159 @default.
- W3199749872 cites W2019666743 @default.
- W3199749872 cites W2023097882 @default.
- W3199749872 cites W2025264090 @default.
- W3199749872 cites W2032143075 @default.
- W3199749872 cites W2034677002 @default.
- W3199749872 cites W2043485993 @default.
- W3199749872 cites W2044794349 @default.
- W3199749872 cites W2049980461 @default.
- W3199749872 cites W2053093934 @default.
- W3199749872 cites W2056801995 @default.
- W3199749872 cites W2057081497 @default.
- W3199749872 cites W2061555550 @default.
- W3199749872 cites W2065345677 @default.
- W3199749872 cites W2066588057 @default.
- W3199749872 cites W2070672521 @default.
- W3199749872 cites W2074939226 @default.
- W3199749872 cites W2076225406 @default.
- W3199749872 cites W2082463555 @default.
- W3199749872 cites W2094115656 @default.
- W3199749872 cites W2094199657 @default.
- W3199749872 cites W2120287323 @default.
- W3199749872 cites W2122283306 @default.
- W3199749872 cites W2150277967 @default.
- W3199749872 cites W2156605766 @default.
- W3199749872 cites W2169364099 @default.
- W3199749872 cites W2171122741 @default.
- W3199749872 cites W2189021327 @default.
- W3199749872 cites W2208426424 @default.
- W3199749872 cites W2460164490 @default.
- W3199749872 cites W2590030951 @default.
- W3199749872 cites W2592888144 @default.
- W3199749872 cites W2741112276 @default.
- W3199749872 cites W2768919282 @default.
- W3199749872 cites W2791109629 @default.
- W3199749872 cites W2806249186 @default.
- W3199749872 cites W2806967619 @default.
- W3199749872 cites W2889105608 @default.
- W3199749872 cites W3012414406 @default.
- W3199749872 cites W3021208261 @default.
- W3199749872 cites W3039838730 @default.
- W3199749872 cites W3047771917 @default.
- W3199749872 doi "https://doi.org/10.1016/j.jconrel.2021.09.021" @default.
- W3199749872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34563590" @default.
- W3199749872 hasPublicationYear "2021" @default.
- W3199749872 type Work @default.
- W3199749872 sameAs 3199749872 @default.
- W3199749872 citedByCount "3" @default.
- W3199749872 countsByYear W31997498722022 @default.
- W3199749872 countsByYear W31997498722023 @default.
- W3199749872 crossrefType "journal-article" @default.
- W3199749872 hasAuthorship W3199749872A5020902504 @default.
- W3199749872 hasAuthorship W3199749872A5044083323 @default.
- W3199749872 hasAuthorship W3199749872A5055685732 @default.
- W3199749872 hasAuthorship W3199749872A5056636389 @default.
- W3199749872 hasAuthorship W3199749872A5077178717 @default.
- W3199749872 hasAuthorship W3199749872A5078188641 @default.
- W3199749872 hasConcept C104317684 @default.
- W3199749872 hasConcept C135983454 @default.
- W3199749872 hasConcept C185592680 @default.
- W3199749872 hasConcept C22615655 @default.
- W3199749872 hasConcept C24107716 @default.
- W3199749872 hasConcept C54009773 @default.
- W3199749872 hasConcept C55493867 @default.
- W3199749872 hasConcept C86803240 @default.
- W3199749872 hasConcept C95444343 @default.
- W3199749872 hasConceptScore W3199749872C104317684 @default.
- W3199749872 hasConceptScore W3199749872C135983454 @default.
- W3199749872 hasConceptScore W3199749872C185592680 @default.
- W3199749872 hasConceptScore W3199749872C22615655 @default.
- W3199749872 hasConceptScore W3199749872C24107716 @default.
- W3199749872 hasConceptScore W3199749872C54009773 @default.
- W3199749872 hasConceptScore W3199749872C55493867 @default.
- W3199749872 hasConceptScore W3199749872C86803240 @default.
- W3199749872 hasConceptScore W3199749872C95444343 @default.
- W3199749872 hasLocation W31997498721 @default.
- W3199749872 hasLocation W31997498722 @default.
- W3199749872 hasOpenAccess W3199749872 @default.