Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199758005> ?p ?o ?g. }
- W3199758005 endingPage "857" @default.
- W3199758005 startingPage "837" @default.
- W3199758005 abstract "To date, although the microscopic alterations present in Alzheimer's disease (AD) have been well known for over a century only a handful of symptomatic treatments have been developed which are a far cry from a full cure providing volatile benefits. In this context, the intervention of stem cell therapy (SCT) has been proposed as an auxiliary treatment for AD as suggested by the rising number of pre-clinical studies that stem cell engraftment could provide an exciting future treatment regimen against neurodegeneration. Although, most of the primary enthusiasm about this approach was based on replacing deteriorating neurons, the latest studies have implied that the positive modulations fostered by stem cells are fuelled by bystander effects. Present review provides a detailed update on stem cell therapy for AD along with meticulous discussion regarding challenges in developing different stem cells from an aspect of experiment to clinical research and their potential in the milieu of AD hallmarks. Specifically, we focus and provide in depth view on recent advancements in the discipline of SCT aiming to repopulate or regenerate the degenerating neuronal circuitry in AD using stem-cell-on-a-chip and 3D bioprinting techniques. The focus is specifically on the successful restoration of cognitive functions upon engraftment of stem cells on in vivo models for the benefit of the current researchers and their understanding about the status of SCT in AD and finally summarizing on what future holds for SCT in the treatment of AD." @default.
- W3199758005 created "2021-09-27" @default.
- W3199758005 creator A5004521608 @default.
- W3199758005 creator A5052441718 @default.
- W3199758005 date "2021-10-01" @default.
- W3199758005 modified "2023-09-28" @default.
- W3199758005 title "Engrafted stem cell therapy for Alzheimer's disease: A promising treatment strategy with clinical outcome" @default.
- W3199758005 cites W1162470753 @default.
- W3199758005 cites W1560839247 @default.
- W3199758005 cites W1597163915 @default.
- W3199758005 cites W1841850981 @default.
- W3199758005 cites W1860197952 @default.
- W3199758005 cites W1971402768 @default.
- W3199758005 cites W1979855408 @default.
- W3199758005 cites W1983515650 @default.
- W3199758005 cites W1992201222 @default.
- W3199758005 cites W1994088950 @default.
- W3199758005 cites W2014386715 @default.
- W3199758005 cites W2015484447 @default.
- W3199758005 cites W2046478450 @default.
- W3199758005 cites W2062146084 @default.
- W3199758005 cites W2064849361 @default.
- W3199758005 cites W2068165326 @default.
- W3199758005 cites W2073157841 @default.
- W3199758005 cites W2073523882 @default.
- W3199758005 cites W2076412273 @default.
- W3199758005 cites W2086943348 @default.
- W3199758005 cites W2089081506 @default.
- W3199758005 cites W2090289365 @default.
- W3199758005 cites W2094514360 @default.
- W3199758005 cites W2096283128 @default.
- W3199758005 cites W2096721251 @default.
- W3199758005 cites W2099150220 @default.
- W3199758005 cites W2107776925 @default.
- W3199758005 cites W2113716161 @default.
- W3199758005 cites W2119807453 @default.
- W3199758005 cites W2123442964 @default.
- W3199758005 cites W2125908939 @default.
- W3199758005 cites W2130128490 @default.
- W3199758005 cites W2134730244 @default.
- W3199758005 cites W2139780621 @default.
- W3199758005 cites W2142360016 @default.
- W3199758005 cites W2144750363 @default.
- W3199758005 cites W2151861723 @default.
- W3199758005 cites W2172587761 @default.
- W3199758005 cites W2173210451 @default.
- W3199758005 cites W2230515417 @default.
- W3199758005 cites W2265799967 @default.
- W3199758005 cites W2322740280 @default.
- W3199758005 cites W2331824792 @default.
- W3199758005 cites W2515072293 @default.
- W3199758005 cites W2515262002 @default.
- W3199758005 cites W2518209427 @default.
- W3199758005 cites W2556456924 @default.
- W3199758005 cites W2567655141 @default.
- W3199758005 cites W2588665420 @default.
- W3199758005 cites W2590949976 @default.
- W3199758005 cites W2591293787 @default.
- W3199758005 cites W2599312235 @default.
- W3199758005 cites W2600233768 @default.
- W3199758005 cites W2611295362 @default.
- W3199758005 cites W2613737923 @default.
- W3199758005 cites W2619544969 @default.
- W3199758005 cites W2765312115 @default.
- W3199758005 cites W2765408167 @default.
- W3199758005 cites W2786597162 @default.
- W3199758005 cites W2789510077 @default.
- W3199758005 cites W2789861219 @default.
- W3199758005 cites W2795744705 @default.
- W3199758005 cites W2805798400 @default.
- W3199758005 cites W2806280791 @default.
- W3199758005 cites W2806602944 @default.
- W3199758005 cites W2883266723 @default.
- W3199758005 cites W2883350768 @default.
- W3199758005 cites W2884209589 @default.
- W3199758005 cites W2887532069 @default.
- W3199758005 cites W2887604256 @default.
- W3199758005 cites W2889829380 @default.
- W3199758005 cites W2893177846 @default.
- W3199758005 cites W2898464988 @default.
- W3199758005 cites W2902499520 @default.
- W3199758005 cites W2903506986 @default.
- W3199758005 cites W2904344678 @default.
- W3199758005 cites W2906413711 @default.
- W3199758005 cites W2913604250 @default.
- W3199758005 cites W2923624073 @default.
- W3199758005 cites W2938006872 @default.
- W3199758005 cites W2943553419 @default.
- W3199758005 cites W2946202410 @default.
- W3199758005 cites W2946268805 @default.
- W3199758005 cites W2950403739 @default.
- W3199758005 cites W2953365051 @default.
- W3199758005 cites W2965634581 @default.
- W3199758005 cites W2966642577 @default.
- W3199758005 cites W2967533534 @default.
- W3199758005 cites W2967895705 @default.
- W3199758005 cites W2975436161 @default.
- W3199758005 cites W2980184539 @default.