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- W3199769720 abstract "Excess nutrient uptake and altered hormone secretion in the gut contribute to a systemic energy imbalance, which causes obesity and an increased risk of type 2 diabetes and colorectal cancer. This functional maladaptation is thought to emerge at the level of the intestinal stem cells (ISCs). However, it is not clear how an obesogenic diet affects ISC identity and fate. Here we show that an obesogenic diet induces ISC and progenitor hyperproliferation, enhances ISC differentiation and cell turnover and changes the regional identities of ISCs and enterocytes in mice. Single-cell resolution of the enteroendocrine lineage reveals an increase in progenitors and peptidergic enteroendocrine cell types and a decrease in serotonergic enteroendocrine cell types. Mechanistically, we link increased fatty acid synthesis, Ppar signaling and the Insr-Igf1r-Akt pathway to mucosal changes. This study describes molecular mechanisms of diet-induced intestinal maladaptation that promote obesity and therefore underlie the pathogenesis of the metabolic syndrome and associated complications." @default.
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- W3199769720 date "2021-09-22" @default.
- W3199769720 modified "2023-10-15" @default.
- W3199769720 title "Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice" @default.
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- W3199769720 cites W1969734540 @default.
- W3199769720 cites W1971194480 @default.
- W3199769720 cites W1982603620 @default.
- W3199769720 cites W1999027849 @default.
- W3199769720 cites W2008424772 @default.
- W3199769720 cites W2015238221 @default.
- W3199769720 cites W2021370278 @default.
- W3199769720 cites W2022068139 @default.
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- W3199769720 cites W2159728029 @default.
- W3199769720 cites W2160234571 @default.
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- W3199769720 cites W2290001148 @default.
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- W3199769720 cites W2485884487 @default.
- W3199769720 cites W2594490173 @default.
- W3199769720 cites W2607031541 @default.
- W3199769720 cites W2611159081 @default.
- W3199769720 cites W2621361823 @default.
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- W3199769720 doi "https://doi.org/10.1038/s42255-021-00458-9" @default.
- W3199769720 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8458097" @default.
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