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• W3199777711 abstract "Childhood trauma (CT) is associated with altered brain anatomy. These neuroanatomical changes might be more pronounced in individuals with a psychiatric disorder. Post-traumatic stress disorder (PTSD) and borderline personality disorder (BPD) are more prevalent in individuals with a history of CT.In this study, we examined limbic and total brain volumes in healthy women with and without a history of CT and in females with PTSD or BPD and a history of CT to see whether neuroanatomical changes are a function of psychopathology or CT.In total, 128 women (N = 70 healthy controls without CT, N = 25 healthy controls with CT, N = 14 individuals with PTSD, and N = 19 individuals with BPD) were recruited. A T1-weighted anatomical MRI was acquired from all participants for Freesurfer-based assessment of total brain, hippocampus, and amygdala volumes. Severity of CT was assessed with a clinical interview and the Childhood Trauma Questionnaire. Group differences in hippocampal and amygdala volumes (adjusted for total brain volume) and total brain volume (adjusted for height) were characterized by analysis of covariance.Volume of the total brain, hippocampus, and amygdala did not differ between the four groups (p > .05). CT severity correlated negatively with total brain volume across groups (r = -0.20; p = .029).CT was associated with reduced brain volume but PTSD or BPD was not. The association between CT and reduced brain volume as a global measure of brain integrity suggests a common origin for vulnerability to psychiatric disorders later in life.Antecedentes: El trauma infantil (TI) se asocia con alteraciones en la anatomía cerebral. Estos cambios neuroanatómicos pueden ser más pronunciados en individuos con trastornos psiquiátricos. El trastorno de estrés postraumático (TEPT) y el trastorno de personalidad limítrofe (TPL) son más prevalentes en individuos con historia de TI.Objetivo: En este estudio, examinamos los volúmenes límbico y cerebral total en mujeres sanas con y sin historia de TI y mujeres con TEPT o TPL e historia de TI para ver si los cambios neuroanatómicos son una función de la psicopatología o del TI.Método: En total, 128 mujeres (N= 70 controles sanas sin TI, N= 25 controles sanas con TI, N= 14 individuos con TEPT y N= 19 individuos con TPL) fueron reclutadas. Se obtuvo una RNM anatómica ponderada en T1 de todas las participantes para la evaluación basada en Freesurfer de los volúmenes totales del cerebro, hipocampo y amígdala. La severidad del TI fue evaluada con una entrevista clínica y con el Cuestionario de Trauma Infantil. Las diferencias grupales en los volúmenes del hipocampo y amígdala (ajustadas por el volumen cerebral total) y el volumen cerebral total (ajustadas por altura) se caracterizaron mediante análisis de covarianza.Resultados: El volumen total del cerebro, hipocampo y amígdala no difirieron entre los cuatro grupos (p > .05). La severidad del TI se correlacionó negativamente con el volumen cerebral total en todos los grupos (r = −0.20; p =.29).Conclusiones: El TI estuvo asociado a un volumen cerebral reducido, pero el TEPT o TPL no se asociaron. La asociación entre TI y volumen cerebral disminuido como una medida global de la integridad cerebral sugiere un origen común de vulnerabilidad a los trastornos psiquiátricos más adelante en la vida.背景:童年期创伤 (CT) 与大脑解剖结构的改变有关。这些神经解剖学变化在患有精神障碍的个体中可能更为明显。创伤后应激障碍 (PTSD) 和边缘型人格障碍 (BPD) 在有 CT 历史的个体中更为普遍。目的:在本研究中, 我们考查了有和没有 CT 历史的健康女性以及有 CT 历史的PTSD 或 BPD 女性患者的边缘系统和总脑容量, 以确定神经解剖学变化是精神病理学还是 CT 的一个函数。方法:总共招募了 128 名女性 (N= 70 名没有 CT 的健康对照, N= 25 名有 CT 的健康对照, N= 14 名PTSD 患者和 N= 19 名BPD 患者) 。从所有参与者处获取 T1 加权解剖 MRI, 用于基于 Freesurfer 的全脑, 海马和杏仁核体积评估。 CT 严重程度通过临床访谈和童年期创伤问卷进行评估。通过协方差分析来刻画海马和杏仁核体积 (控制总脑容量) 和总脑容量 (控制身高) 的组间差异。结果:四组之间的总脑, 海马和杏仁核的体积没有差异 (p> .05) 。 CT 严重程度与各组的总脑容量呈负相关 (r = −0.20; p=.029) 。结论:CT 与脑容量减少有关, 但 PTSD 或 BPD 则不然。 CT 与作为大脑完整性整体测量的脑容量减少之间的关联, 提示这是日后生活中易感精神障碍的一个常见原因." @default.
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• W3199777711 date "2021-01-01" @default.
• W3199777711 modified "2023-10-02" @default.
• W3199777711 title "Association between childhood trauma and brain anatomy in women with post-traumatic stress disorder, women with borderline personality disorder, and healthy women" @default.
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• W3199777711 cites W1980508260 @default.
• W3199777711 cites W1980704757 @default.
• W3199777711 cites W1987375729 @default.
• W3199777711 cites W1990427757 @default.
• W3199777711 cites W1992600467 @default.
• W3199777711 cites W1995833874 @default.
• W3199777711 cites W1999889452 @default.
• W3199777711 cites W2002899263 @default.
• W3199777711 cites W2004293194 @default.
• W3199777711 cites W2010523062 @default.
• W3199777711 cites W2011771510 @default.
• W3199777711 cites W2018630482 @default.
• W3199777711 cites W2036194871 @default.
• W3199777711 cites W2038055792 @default.
• W3199777711 cites W2039620318 @default.
• W3199777711 cites W2040546819 @default.
• W3199777711 cites W2044109612 @default.
• W3199777711 cites W2046297778 @default.
• W3199777711 cites W2051497909 @default.
• W3199777711 cites W2053643651 @default.
• W3199777711 cites W2059428488 @default.
• W3199777711 cites W2062682953 @default.
• W3199777711 cites W2062989629 @default.
• W3199777711 cites W2064212981 @default.
• W3199777711 cites W2077552311 @default.
• W3199777711 cites W2092481091 @default.
• W3199777711 cites W2099527079 @default.
• W3199777711 cites W2106344090 @default.
• W3199777711 cites W2107983778 @default.
• W3199777711 cites W2112262501 @default.
• W3199777711 cites W2118439943 @default.
• W3199777711 cites W2135890562 @default.
• W3199777711 cites W2136086850 @default.
• W3199777711 cites W2141045284 @default.
• W3199777711 cites W2142644111 @default.
• W3199777711 cites W2142684707 @default.
• W3199777711 cites W2143323047 @default.
• W3199777711 cites W2162196924 @default.
• W3199777711 cites W2164039729 @default.
• W3199777711 cites W2166401337 @default.
• W3199777711 cites W2168963412 @default.
• W3199777711 cites W2171097731 @default.
• W3199777711 cites W2266560836 @default.
• W3199777711 cites W2403749440 @default.
• W3199777711 cites W2522772114 @default.
• W3199777711 cites W2523665179 @default.
• W3199777711 cites W2541221342 @default.
• W3199777711 cites W2581084710 @default.
• W3199777711 cites W2590133125 @default.
• W3199777711 cites W2606252413 @default.
• W3199777711 cites W2625994392 @default.
• W3199777711 cites W2772371211 @default.
• W3199777711 cites W2790177302 @default.
• W3199777711 cites W2796110790 @default.
• W3199777711 cites W2884899764 @default.
• W3199777711 cites W2905562542 @default.
• W3199777711 cites W2914765137 @default.
• W3199777711 cites W2954276404 @default.
• W3199777711 cites W2964592010 @default.
• W3199777711 cites W2970540284 @default.
• W3199777711 cites W2990458304 @default.
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• W3199777711 doi "https://doi.org/10.1080/20008198.2021.1959706" @default.
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