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- W3199782407 abstract "Doxorubicin (DOX) is widely prescribed for the treatment of several human cancers. Unfortunately, cumulative doses of DOX are the main cause of myocardial dysfunction. Although preclinical and pharmaceutical studies were performed to investigate the potential of natural compounds in minimizing DOX toxicity, a comprehensive review of them is not available. This review can help the researchers for an effective search strategy.Oxidative stress and p53 play an important role in DOX-associated cardiotoxicity. DOX activates nicotinamide adenine dinucleotide phosphate NADPH oxidase (NOX) in the heart, resulting in excessive reactive oxygen species that can induce cardiomyocyte apoptosis through phosphorylation of p53, DNA damage and/or mitogen-activated protein kinases-mediated cardiomyocyte apoptosis. Although a few chemical drugs with high efficacy are administered along with DOX to prevent or more likely to reduce cardiovascular toxicity, their use is often limited by additional side effects. Recently, attention has been drawn to natural compounds that prevent DOX cardiotoxicity. This review focuses on some of the natural bioactive compounds with potential therapeutic efficacy against DOX-induced cardiotoxicity (DIC).Some natural compounds, especially flavonols, flavonoids and proanthocyanidins, have the most protective effects against DIC by forming stable radicals and preventing the assembly of the NOX subunits." @default.
- W3199782407 created "2021-09-27" @default.
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- W3199782407 creator A5091386382 @default.
- W3199782407 date "2021-09-25" @default.
- W3199782407 modified "2023-09-27" @default.
- W3199782407 title "The Protective Effect of Natural Compounds on Doxorubicin-Induced Cardiotoxicity via Nicotinamide Adenine Dinucleotide Phosphate Oxidase Inhibition" @default.
- W3199782407 cites W1517318768 @default.
- W3199782407 cites W1526856981 @default.
- W3199782407 cites W1527034886 @default.
- W3199782407 cites W1530259969 @default.
- W3199782407 cites W1697086437 @default.
- W3199782407 cites W1965759641 @default.
- W3199782407 cites W1970736611 @default.
- W3199782407 cites W1975588412 @default.
- W3199782407 cites W1975927340 @default.
- W3199782407 cites W1983338915 @default.
- W3199782407 cites W1986108540 @default.
- W3199782407 cites W1988079533 @default.
- W3199782407 cites W1988097865 @default.
- W3199782407 cites W1990450803 @default.
- W3199782407 cites W1992779539 @default.
- W3199782407 cites W1992985485 @default.
- W3199782407 cites W1993615940 @default.
- W3199782407 cites W1998331064 @default.
- W3199782407 cites W1998950914 @default.
- W3199782407 cites W2000922007 @default.
- W3199782407 cites W2010183849 @default.
- W3199782407 cites W2010675090 @default.
- W3199782407 cites W2013903004 @default.
- W3199782407 cites W2020355048 @default.
- W3199782407 cites W2022106942 @default.
- W3199782407 cites W2025236490 @default.
- W3199782407 cites W2025849489 @default.
- W3199782407 cites W2028328784 @default.
- W3199782407 cites W2033324588 @default.
- W3199782407 cites W2036225919 @default.
- W3199782407 cites W2038053883 @default.
- W3199782407 cites W2040850983 @default.
- W3199782407 cites W2041088774 @default.
- W3199782407 cites W2042232868 @default.
- W3199782407 cites W2046746329 @default.
- W3199782407 cites W2048218903 @default.
- W3199782407 cites W2051258629 @default.
- W3199782407 cites W2054199981 @default.
- W3199782407 cites W2055561163 @default.
- W3199782407 cites W2056972102 @default.
- W3199782407 cites W2070017937 @default.
- W3199782407 cites W2071644397 @default.
- W3199782407 cites W2076315300 @default.
- W3199782407 cites W2081667757 @default.
- W3199782407 cites W2085128107 @default.
- W3199782407 cites W2085163888 @default.
- W3199782407 cites W2089923455 @default.
- W3199782407 cites W2090102281 @default.
- W3199782407 cites W2090739441 @default.
- W3199782407 cites W2093557429 @default.
- W3199782407 cites W2096094438 @default.
- W3199782407 cites W2107701861 @default.
- W3199782407 cites W2109069677 @default.
- W3199782407 cites W2112300595 @default.
- W3199782407 cites W2125974556 @default.
- W3199782407 cites W2133349278 @default.
- W3199782407 cites W2138653366 @default.
- W3199782407 cites W2153463588 @default.
- W3199782407 cites W2153599061 @default.
- W3199782407 cites W2157588585 @default.
- W3199782407 cites W2172510441 @default.
- W3199782407 cites W2180093027 @default.
- W3199782407 cites W2197691287 @default.
- W3199782407 cites W2199498591 @default.
- W3199782407 cites W2333078188 @default.
- W3199782407 cites W2462614594 @default.
- W3199782407 cites W2620054758 @default.
- W3199782407 cites W2621309837 @default.
- W3199782407 cites W2741280074 @default.
- W3199782407 cites W2748053146 @default.
- W3199782407 cites W2755290410 @default.
- W3199782407 cites W2776105170 @default.
- W3199782407 cites W2777848148 @default.
- W3199782407 cites W2885067533 @default.
- W3199782407 cites W2951874890 @default.
- W3199782407 cites W2952015957 @default.
- W3199782407 cites W2995420453 @default.
- W3199782407 cites W3112431073 @default.
- W3199782407 cites W4234381551 @default.
- W3199782407 doi "https://doi.org/10.1093/jpp/rgab109" @default.
- W3199782407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34562089" @default.
- W3199782407 hasPublicationYear "2021" @default.
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