FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199786487> ?p ?o ?g. }

• W3199786487 endingPage "5770" @default.
• W3199786487 startingPage "5761" @default.
• W3199786487 abstract "Abstract Evidence from animal and histological studies has indicated that accumulation of iron in the brain results in reactive gliosis that contributes to cognitive deficits. The current study extends these findings to human cognitive aging and suggests that magnetic resonance imaging (MRI) techniques like quantitative relaxometry can be used to study iron and its effects in vivo. The effects of iron on microstructure and memory performance were examined using a combination of quantitative relaxometry and multicompartment diffusion imaging in 35 young (21.06 ± 2.18 years) and 28 older (72.58 ± 6.47 years) adults, who also completed a memory task. Replicating past work, results revealed age‐related increases in iron content (R2*) and diffusion, and decreases in memory performance. Independent of age group, iron content was significantly related to restricted (intracellular) diffusion in regions with low‐moderate iron (hippocampus, caudate) and to all diffusion metrics in regions with moderate‐high iron (putamen, globus pallidus). This pattern is consistent with different stages of iron‐related gliosis, ranging from astrogliosis that may influence intracellular diffusion to microglial proliferation and increased vascular permeability that may influence all sources of diffusion. Further, hippocampal restricted diffusion was significantly related to memory performance, with a third of this effect related to iron content; consistent with the hypothesis that higher iron‐related astrogliosis in the hippocampus is associated with poorer memory performance. These results demonstrate the sensitivity of MRI to iron‐related gliosis and extend our understanding of its impact on cognition by showing that this relationship also explains individual differences in memory performance." @default.
• W3199786487 created "2021-09-27" @default.
• W3199786487 creator A5001741472 @default.
• W3199786487 creator A5010356510 @default.
• W3199786487 creator A5017673477 @default.
• W3199786487 date "2021-09-14" @default.
• W3199786487 modified "2023-09-30" @default.
• W3199786487 title "Neuroimaging measures of iron and gliosis explain memory performance in aging" @default.
• W3199786487 cites W1573719164 @default.
• W3199786487 cites W1967301594 @default.
• W3199786487 cites W1967922486 @default.
• W3199786487 cites W1978985638 @default.
• W3199786487 cites W1979871416 @default.
• W3199786487 cites W1981835221 @default.
• W3199786487 cites W1984453610 @default.
• W3199786487 cites W1999836898 @default.
• W3199786487 cites W2006207066 @default.
• W3199786487 cites W2015896685 @default.
• W3199786487 cites W2023658755 @default.
• W3199786487 cites W2025183354 @default.
• W3199786487 cites W2029224753 @default.
• W3199786487 cites W2032254014 @default.
• W3199786487 cites W2036969062 @default.
• W3199786487 cites W2044702446 @default.
• W3199786487 cites W2047585900 @default.
• W3199786487 cites W2057241064 @default.
• W3199786487 cites W2063804160 @default.
• W3199786487 cites W2067361755 @default.
• W3199786487 cites W2073391734 @default.
• W3199786487 cites W2082449493 @default.
• W3199786487 cites W2089527131 @default.
• W3199786487 cites W2089940272 @default.
• W3199786487 cites W2090348107 @default.
• W3199786487 cites W2099448948 @default.
• W3199786487 cites W2113525383 @default.
• W3199786487 cites W2117140276 @default.
• W3199786487 cites W2119036728 @default.
• W3199786487 cites W2124603839 @default.
• W3199786487 cites W2125068099 @default.
• W3199786487 cites W2127309075 @default.
• W3199786487 cites W2140073946 @default.
• W3199786487 cites W2147426453 @default.
• W3199786487 cites W2157723935 @default.
• W3199786487 cites W2157974947 @default.
• W3199786487 cites W2160935383 @default.
• W3199786487 cites W2165758561 @default.
• W3199786487 cites W2174979518 @default.
• W3199786487 cites W2175004183 @default.
• W3199786487 cites W2236070949 @default.
• W3199786487 cites W2276374746 @default.
• W3199786487 cites W2413955537 @default.
• W3199786487 cites W2588031085 @default.
• W3199786487 cites W2593955492 @default.
• W3199786487 cites W2596717566 @default.
• W3199786487 cites W2747366609 @default.
• W3199786487 cites W2752042669 @default.
• W3199786487 cites W2762310135 @default.
• W3199786487 cites W2791084533 @default.
• W3199786487 cites W2905411333 @default.
• W3199786487 cites W2915889393 @default.
• W3199786487 cites W2969876301 @default.
• W3199786487 cites W2975734873 @default.
• W3199786487 cites W2977883299 @default.
• W3199786487 cites W2990298546 @default.
• W3199786487 cites W3016238554 @default.
• W3199786487 cites W3025780063 @default.
• W3199786487 cites W3048625360 @default.
• W3199786487 cites W3090103921 @default.
• W3199786487 cites W3199786487 @default.
• W3199786487 cites W4239346618 @default.
• W3199786487 cites W941967958 @default.
• W3199786487 doi "https://doi.org/10.1002/hbm.25652" @default.
• W3199786487 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8559505" @default.
• W3199786487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34520095" @default.
• W3199786487 hasPublicationYear "2021" @default.
• W3199786487 type Work @default.
• W3199786487 sameAs 3199786487 @default.
• W3199786487 citedByCount "7" @default.
• W3199786487 countsByYear W31997864872021 @default.
• W3199786487 countsByYear W31997864872022 @default.
• W3199786487 crossrefType "journal-article" @default.
• W3199786487 hasAuthorship W3199786487A5001741472 @default.
• W3199786487 hasAuthorship W3199786487A5010356510 @default.
• W3199786487 hasAuthorship W3199786487A5017673477 @default.
• W3199786487 hasBestOaLocation W31997864871 @default.
• W3199786487 hasConcept C126838900 @default.
• W3199786487 hasConcept C143409427 @default.
• W3199786487 hasConcept C148762608 @default.
• W3199786487 hasConcept C149550507 @default.
• W3199786487 hasConcept C15744967 @default.
• W3199786487 hasConcept C169760540 @default.
• W3199786487 hasConcept C2777682930 @default.
• W3199786487 hasConcept C2778187257 @default.
• W3199786487 hasConcept C2779714222 @default.
• W3199786487 hasConcept C2779965356 @default.
• W3199786487 hasConcept C2780278869 @default.
• W3199786487 hasConcept C2781161787 @default.
• W3199786487 hasConcept C529278444 @default.

• next