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- W3199792850 endingPage "204512532110458" @default.
- W3199792850 startingPage "204512532110458" @default.
- W3199792850 abstract "Bipolar disorder (BD) is a cyclic mood disorder characterised by alternating episodes of mania/hypomania and depression interspersed with euthymic periods. Lamotrigine (LTG) demonstrated some mood improvement in patients treated for epilepsy, leading to clinical studies in patients with BD and its eventual introduction as maintenance therapy for the prevention of depressive relapse in euthymic patients. Most current clinical guidelines include LTG as a recommended treatment option for the maintenance phase in adult BD, consistent with its global licencing status.To review the evidence for the efficacy and safety of LTG in the treatment of all phases of BD.PubMed was searched for double-blind, randomised, placebo-controlled trials using the keywords: LTG, Lamictal, 'bipolar disorder', 'bipolar affective disorder', 'bipolar I', 'bipolar II', cyclothymia, mania, manic, depression, depressive, 'randomised controlled trial', 'randomised trial', RCT and 'placebo-controlled' and corresponding MeSH terms. Eligible articles published in English were reviewed.Thirteen studies were identified. The strongest evidence supports utility in the prevention of recurrence and relapse, particularly depressive relapse, in stabilised patients. Some evidence suggests efficacy in acute bipolar depression, but findings are inconsistent. There is little or no strong evidence in support of efficacy in acute mania, unipolar depression, or rapid-cycling BD. Few controlled trials have evaluated LTG in bipolar II or in paediatric patients. Indications for safety, tolerability and patient acceptability are relatively favourable, provided there is slow dose escalation to reduce the probability of skin rash.On the balance of efficacy and tolerability, LTG might be considered a first-line drug for BD, except for acute manic episodes or where rapid symptom control is required. In terms of efficacy alone, however, the evidence favours other medications." @default.
- W3199792850 created "2021-09-27" @default.
- W3199792850 creator A5007125321 @default.
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- W3199792850 creator A5040670651 @default.
- W3199792850 creator A5084272224 @default.
- W3199792850 date "2021-01-01" @default.
- W3199792850 modified "2023-10-10" @default.
- W3199792850 title "Efficacy and safety of lamotrigine in the treatment of bipolar disorder across the lifespan: a systematic review" @default.
- W3199792850 cites W1490350884 @default.
- W3199792850 cites W1492543930 @default.
- W3199792850 cites W1497087603 @default.
- W3199792850 cites W1558902017 @default.
- W3199792850 cites W1562663508 @default.
- W3199792850 cites W1593754392 @default.
- W3199792850 cites W1603664273 @default.
- W3199792850 cites W1607338306 @default.
- W3199792850 cites W1775625244 @default.
- W3199792850 cites W1920630467 @default.
- W3199792850 cites W1930195718 @default.
- W3199792850 cites W1964012438 @default.
- W3199792850 cites W1966884017 @default.
- W3199792850 cites W1967735031 @default.
- W3199792850 cites W1973735336 @default.
- W3199792850 cites W1975807583 @default.
- W3199792850 cites W1976470591 @default.
- W3199792850 cites W1977252830 @default.
- W3199792850 cites W1978551870 @default.
- W3199792850 cites W1981985293 @default.
- W3199792850 cites W1984344128 @default.
- W3199792850 cites W1985086901 @default.
- W3199792850 cites W1985361282 @default.
- W3199792850 cites W1991568138 @default.
- W3199792850 cites W1991621530 @default.
- W3199792850 cites W1991947158 @default.
- W3199792850 cites W1994993877 @default.
- W3199792850 cites W1996158922 @default.
- W3199792850 cites W2000825037 @default.
- W3199792850 cites W2003490971 @default.
- W3199792850 cites W2005573788 @default.
- W3199792850 cites W2007339452 @default.
- W3199792850 cites W2010680811 @default.
- W3199792850 cites W2011797837 @default.
- W3199792850 cites W2011887687 @default.
- W3199792850 cites W2012476442 @default.
- W3199792850 cites W2014522439 @default.
- W3199792850 cites W2016245249 @default.
- W3199792850 cites W2016955429 @default.
- W3199792850 cites W2018213236 @default.
- W3199792850 cites W2018567081 @default.
- W3199792850 cites W2020592888 @default.
- W3199792850 cites W2021722452 @default.
- W3199792850 cites W2022487862 @default.
- W3199792850 cites W2026664943 @default.
- W3199792850 cites W2032592734 @default.
- W3199792850 cites W2033336706 @default.
- W3199792850 cites W2037231243 @default.
- W3199792850 cites W2037715064 @default.
- W3199792850 cites W2039273279 @default.
- W3199792850 cites W2039694463 @default.
- W3199792850 cites W2041668107 @default.
- W3199792850 cites W2041983408 @default.
- W3199792850 cites W2042086859 @default.
- W3199792850 cites W2043129828 @default.
- W3199792850 cites W2046597861 @default.
- W3199792850 cites W2047612847 @default.
- W3199792850 cites W2049517853 @default.
- W3199792850 cites W2050019610 @default.
- W3199792850 cites W2050035009 @default.
- W3199792850 cites W2053399522 @default.
- W3199792850 cites W2055121490 @default.
- W3199792850 cites W2057892905 @default.
- W3199792850 cites W2058120764 @default.
- W3199792850 cites W2061070907 @default.
- W3199792850 cites W2063250117 @default.
- W3199792850 cites W206402686 @default.
- W3199792850 cites W2064478935 @default.
- W3199792850 cites W2064876927 @default.
- W3199792850 cites W2065130340 @default.
- W3199792850 cites W2066690632 @default.
- W3199792850 cites W2068642098 @default.
- W3199792850 cites W2070454612 @default.
- W3199792850 cites W2072748137 @default.
- W3199792850 cites W2074038654 @default.
- W3199792850 cites W2076472832 @default.
- W3199792850 cites W2078140621 @default.
- W3199792850 cites W2078761132 @default.
- W3199792850 cites W2080724513 @default.
- W3199792850 cites W2080766675 @default.
- W3199792850 cites W2083707448 @default.
- W3199792850 cites W2084399232 @default.
- W3199792850 cites W2088440043 @default.
- W3199792850 cites W2090756864 @default.
- W3199792850 cites W2091830069 @default.
- W3199792850 cites W2095539522 @default.
- W3199792850 cites W2096386877 @default.
- W3199792850 cites W2100691669 @default.
- W3199792850 cites W2109545626 @default.