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• W3199892286 endingPage "102537" @default.
• W3199892286 startingPage "102537" @default.
• W3199892286 abstract "Acne vulgaris is a chronic inflammatory skin disease around pilosebaceous unit. 5-Aminolaevulinic acid photodynamic therapy (ALA-PDT) is an effective therapy for severe acne vulgaris. However, its specific treatment mechanism remains unclear. In the present study, we investigated the potential mechanism of how ALA-PDT induced lipid secretion inhibition in acne vulgaris.Primary human sebocytes and sebaceous gland of golden hamster were treated with/without ALA-PDT. Cell viability was evaluated by Live/Dead Cell assay. Fluorescence microscope was used to observe lipids secretion in sebocytes after Nile red staining. The expression of SREBP-1 after ALA-PDT was evaluated by qRT-PCR. Regulation of ALA-PDT on AMPK/SREBP-1 was evaluated by western blot.The results showed that ALA-PDT suppressed lipid secretion of primary human sebocytes. In addition, ALA-PDT could inhibit the expression of SREBP-1 in vitro. We also found that ALA-PDT activated AMPK pathway, down-regulating the expression of SREBP-1 in sebocytes after ALA-PDT.These findings elucidate that ALA-PDT suppresses lipid secretion through AMPK/SREBP-1 pathway in treatment of acne vulgaris." @default.
• W3199892286 created "2021-09-27" @default.
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• W3199892286 date "2021-12-01" @default.
• W3199892286 modified "2023-10-14" @default.
• W3199892286 title "5-Aminolaevulinic acid photodynamic therapy suppresses lipid secretion of primary sebocytes through AMPK/SREBP-1 pathway" @default.
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• W3199892286 doi "https://doi.org/10.1016/j.pdpdt.2021.102537" @default.
• W3199892286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34536608" @default.
• W3199892286 hasPublicationYear "2021" @default.
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