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• W3199894261 abstract "Abstract Objectives There is a requirement within ear therapeutics for a delivery system capable of safely delivering controlled doses to the inner ear. However, the anatomy and sensitivity of the inner ear make current delivery systems problematic and often ineffective. Therefore, a new delivery system is required to overcome these issues and provide a more efficacious system in the treatment of inner ear disease. This study assesses the potential of 3D printing (3DP) as a fabrication method for an implantable drug delivery system (DDS) to the inner ear. Key findings Three implantable designs of varying geometry were produced with fused deposition modelling (FDM) 3DP, each loaded with 0.25%, 0.5% and 1% levofloxacin; filaments prepared by hot-melt extrusion. Each implant was effective in providing sustained, therapeutic release of levofloxacin for at least 4 days and as such would be effective in therapeutic treatment of many common inner ear diseases, such as otitis media or Ménière’s disease. Conclusions This proof-of-concept research was successful in utilising FDM as a fabrication method for a DDS capable of providing prolonged release directly to the inner ear and highlights the viability of 3DP in the fabrication of an inner ear DDS." @default.
• W3199894261 created "2021-09-27" @default.
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• W3199894261 date "2021-10-19" @default.
• W3199894261 modified "2023-10-16" @default.
• W3199894261 title "Fused deposition modelling 3D printing proof-of-concept study for personalised inner ear therapy" @default.
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• W3199894261 doi "https://doi.org/10.1093/jpp/rgab147" @default.
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• W3199894261 hasPublicationYear "2021" @default.
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