Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199944448> ?p ?o ?g. }
- W3199944448 abstract "An epidemiological association between multiple sclerosis (MS) and inflammatory bowel disease (IBD) is well established, but whether this reflects a shared genetic aetiology, and whether consistent genetic relationships exist between MS and the two predominant IBD subtypes, ulcerative colitis (UC) and Crohn's disease (CD), remains unclear. Here, we use large-scale genome-wide association study summary data to investigate the shared genetic architecture between MS and IBD overall and UC and CD independently. We find a significantly greater genetic correlation between MS and UC than between MS and CD, and identify three SNPs shared between MS and IBD (rs13428812), UC (rs116555563) and CD (rs13428812, rs9977672) in cross-trait meta-analyses. We find suggestive evidence for a causal effect of MS on UC and IBD using Mendelian randomization, but no or weak and inconsistent evidence for a causal effect of IBD or UC on MS. We observe largely consistent patterns of tissue-specific heritability enrichment for MS and IBDs in lung, spleen, whole blood and small intestine, and identify cell-type-specific enrichment for MS and IBDs in CD4+ T cells in lung and CD8+ cytotoxic T cells in lung and spleen. Our study sheds light on the biological basis of comorbidity between MS and IBD." @default.
- W3199944448 created "2021-09-27" @default.
- W3199944448 creator A5018538773 @default.
- W3199944448 creator A5040138901 @default.
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- W3199944448 creator A5063512752 @default.
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- W3199944448 creator A5084229505 @default.
- W3199944448 creator A5091543149 @default.
- W3199944448 date "2021-09-24" @default.
- W3199944448 modified "2023-10-16" @default.
- W3199944448 title "Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases" @default.
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- W3199944448 doi "https://doi.org/10.1038/s41467-021-25768-0" @default.