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• W3199979447 abstract "The synthesis of amides from thiols through a cobalt-catalyzed aminocarbonylation is shown. After optimizing all the reaction parameters, the methodology makes possible the obtention of amides with variable yields, while competing reactions such as the formation of disulfides and ureas can be limited. The process works well with aromatic thiols with electron donating groups (EDG) whereas other thiols give reaction with lower yields. The previous process has been transferred and optimized into flow equipment, thus allowing using less CO in a safer way, and permitting the scaling up of the synthesis. Two drugs, moclobemide and itopride were prepared with this methodology, albeit only in the second case with good results. A mechanistic pathway is proposed." @default.
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• W3199979447 date "2021-01-01" @default.
• W3199979447 modified "2023-10-13" @default.
• W3199979447 title "Cobalt catalysed aminocarbonylation of thiols in batch and flow for the preparation of amides" @default.
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• W3199979447 doi "https://doi.org/10.1039/d1ra04736a" @default.
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