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• W3200010831 abstract "Background: Uveal melanoma is the most commonly occurring primary intraocular malignancy in adults, and patients have a high risk of developing metastatic disease, mostly in the liver. Isolated hepatic perfusion (IHP) with melphalan is a liver-directed therapy for patients with liver metastases. Percutaneous hepatic perfusion (PHP), a minimally invasive technique, is available as well. PHP benefits from the fact that the procedure can be repeated and therefore possibly offers better survival. We conducted a systematic review and meta-analysis comparing both techniques. Methods: A systematic literature search was performed using the electronic databases of Scopus, MEDLINE, Web of Science, PubMed and Cochrane CENTRAL. A total of nine articles reporting on eight studies were included in the analysis. Individual survival data were extracted from each study. Results: The median overall survival (OS) was 17.1 months for IHP and 17.3 months for PHP. The median progression-free survival (PFS) was 7.2 months for IHP and 9.6 months for PHP. The median hepatic progression-free survival was 10 months for IHP and 9.5 months for PHP. The complication rate and 30-day mortality rate were 39.1% and 5.5% for IHP and 23.8% and 1.8% for PHP. Conclusion: There was no difference in OS or PFS between IHP and PHP for patients with uveal melanoma liver metastases, but patients have significantly less of a risk for complications and mortality following PHP." @default.
• W3200010831 created "2021-09-27" @default.
• W3200010831 creator A5014354451 @default.
• W3200010831 creator A5079236953 @default.
• W3200010831 creator A5085535416 @default.
• W3200010831 date "2021-09-21" @default.
• W3200010831 modified "2023-10-17" @default.
• W3200010831 title "Meta-Analysis of Isolated Hepatic Perfusion and Percutaneous Hepatic Perfusion as a Treatment for Uveal Melanoma Liver Metastases" @default.
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• W3200010831 doi "https://doi.org/10.3390/cancers13184726" @default.
• W3200010831 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8469397" @default.
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• W3200010831 hasPublicationYear "2021" @default.
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