FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200048634> ?p ?o ?g. }

• W3200048634 abstract "Atherosclerotic disease is the leading cause of death world-wide with few novel therapies available despite the ongoing health burden. Redox dysfunction is a well-established driver of atherosclerotic progression; however, the clinical translation of redox-based therapies is lacking. One of the challenges facing redox-based therapies is their targeted delivery to cellular domains of redox dysregulation. In the current study, we sought to develop Antioxidant Response Activating nanoParticles (ARAPas), encapsulating redox-based interventions, that exploit macrophage biology and the dysfunctional endothelium in order to selectively accumulate in atherosclerotic plaque. We employed flash nanoprecipitation (FNP) to synthesize bio-compatible polymeric nanoparticles encapsulating the hydrophobic Nrf2 activator drug, CDDO-Methyl (CDDOMe-ARAPas). Nuclear factor erythroid 2-related factor 2 (Nrf2)-activators are a promising class of redox-active drug molecules whereby activation of Nrf2 results in the expression of several antioxidant and cyto-protective enzymes that can be athero-protective. In this study, we characterize the physiochemical properties of CDDOMe-ARAPas as well as confirm their in vitro internalization by murine macrophages. Drug release of CDDOMe was determined by Nrf2-driven GFP fluorescence. Moreover, we show that these CDDOMe-ARAPas exert anti-inflammatory effects in classically activated macrophages. Finally, we show that CDDOMe-ARAPas selectively accumulate in atherosclerotic plaque of two widely-used murine models of atherosclerosis: ApoE-/- and LDLr-/- mice, and are capable of increasing gene expression of Nrf2-transcriptional targets in the atherosclerotic aortic arch. Future work will assess the therapeutic efficacy of intra-plaque Nrf2 activation with CDDOMe-ARAPas to inhibit atherosclerotic plaque progression. Overall, our present studies underline that targeting of atherosclerotic plaque is an effective means to enhance delivery of redox-based interventions." @default.
• W3200048634 created "2021-09-27" @default.
• W3200048634 creator A5010263152 @default.
• W3200048634 creator A5017790825 @default.
• W3200048634 creator A5024926315 @default.
• W3200048634 creator A5046123956 @default.
• W3200048634 creator A5083855701 @default.
• W3200048634 date "2021-09-17" @default.
• W3200048634 modified "2023-10-17" @default.
• W3200048634 title "Antioxidant Response Activating nanoParticles (ARAPas) localize to atherosclerotic plaque and locally activate the Nrf2 pathway" @default.
• W3200048634 cites W1063831131 @default.
• W3200048634 cites W1498773598 @default.
• W3200048634 cites W1855877637 @default.
• W3200048634 cites W1964324812 @default.
• W3200048634 cites W1967070731 @default.
• W3200048634 cites W1979718416 @default.
• W3200048634 cites W1986364810 @default.
• W3200048634 cites W1990424094 @default.
• W3200048634 cites W1993147176 @default.
• W3200048634 cites W2002223683 @default.
• W3200048634 cites W2004832721 @default.
• W3200048634 cites W2008960002 @default.
• W3200048634 cites W2021982396 @default.
• W3200048634 cites W2022582116 @default.
• W3200048634 cites W2029394370 @default.
• W3200048634 cites W2048891783 @default.
• W3200048634 cites W2057907220 @default.
• W3200048634 cites W2059571803 @default.
• W3200048634 cites W2080041249 @default.
• W3200048634 cites W2085103300 @default.
• W3200048634 cites W2087633043 @default.
• W3200048634 cites W2094399039 @default.
• W3200048634 cites W2094629035 @default.
• W3200048634 cites W2098828894 @default.
• W3200048634 cites W2112771838 @default.
• W3200048634 cites W2125670865 @default.
• W3200048634 cites W2129297473 @default.
• W3200048634 cites W2129702814 @default.
• W3200048634 cites W2143506134 @default.
• W3200048634 cites W2158368253 @default.
• W3200048634 cites W2166342596 @default.
• W3200048634 cites W2336820302 @default.
• W3200048634 cites W2400239628 @default.
• W3200048634 cites W2402706228 @default.
• W3200048634 cites W2438649526 @default.
• W3200048634 cites W2577375400 @default.
• W3200048634 cites W2580792129 @default.
• W3200048634 cites W2587769401 @default.
• W3200048634 cites W2592188965 @default.
• W3200048634 cites W2610518082 @default.
• W3200048634 cites W2624985846 @default.
• W3200048634 cites W2763545425 @default.
• W3200048634 cites W2788006236 @default.
• W3200048634 cites W2803219275 @default.
• W3200048634 cites W2804638973 @default.
• W3200048634 cites W2804846127 @default.
• W3200048634 cites W2886665056 @default.
• W3200048634 cites W2908425768 @default.
• W3200048634 cites W2910807499 @default.
• W3200048634 cites W2915113556 @default.
• W3200048634 cites W2920248606 @default.
• W3200048634 cites W2949664510 @default.
• W3200048634 cites W2954146739 @default.
• W3200048634 cites W2954257280 @default.
• W3200048634 cites W2960728349 @default.
• W3200048634 cites W3082264268 @default.
• W3200048634 cites W3145037012 @default.
• W3200048634 doi "https://doi.org/10.1101/2021.09.16.460323" @default.
• W3200048634 hasPublicationYear "2021" @default.
• W3200048634 type Work @default.
• W3200048634 sameAs 3200048634 @default.
• W3200048634 citedByCount "0" @default.
• W3200048634 crossrefType "posted-content" @default.
• W3200048634 hasAuthorship W3200048634A5010263152 @default.
• W3200048634 hasAuthorship W3200048634A5017790825 @default.
• W3200048634 hasAuthorship W3200048634A5024926315 @default.
• W3200048634 hasAuthorship W3200048634A5046123956 @default.
• W3200048634 hasAuthorship W3200048634A5083855701 @default.
• W3200048634 hasBestOaLocation W32000486341 @default.
• W3200048634 hasConcept C104317684 @default.
• W3200048634 hasConcept C139770010 @default.
• W3200048634 hasConcept C170493617 @default.
• W3200048634 hasConcept C178790620 @default.
• W3200048634 hasConcept C185592680 @default.
• W3200048634 hasConcept C202751555 @default.
• W3200048634 hasConcept C2776151105 @default.
• W3200048634 hasConcept C2776529522 @default.
• W3200048634 hasConcept C2778004101 @default.
• W3200048634 hasConcept C2779820397 @default.
• W3200048634 hasConcept C502942594 @default.
• W3200048634 hasConcept C55493867 @default.
• W3200048634 hasConcept C55904794 @default.
• W3200048634 hasConcept C86339819 @default.
• W3200048634 hasConcept C86803240 @default.
• W3200048634 hasConcept C88045685 @default.
• W3200048634 hasConcept C95444343 @default.
• W3200048634 hasConcept C98274493 @default.
• W3200048634 hasConceptScore W3200048634C104317684 @default.
• W3200048634 hasConceptScore W3200048634C139770010 @default.
• W3200048634 hasConceptScore W3200048634C170493617 @default.

• next