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- W3200065914 abstract "Leptin for over 25 years has been a central theme in the study of appetite, obesity, and starvation. As the major site of leptin production is peripheral, and the site of action of greatest interest is the hypothalamus, how leptin accesses the central nervous system (CNS) and crosses the blood-brain barrier (BBB) has been of great interest. We review here the ongoing research that addresses fundamental questions such as the sites of leptin resistances in obesity and other conditions, the causes of resistances and their relations to one another, the three barrier sites of entry into the CNS, why recent studies using suprapharmacological doses cannot address these questions but give insight into nonsaturable entry of leptin into the CNS, and how that might be useful in using leptin therapeutically. The current status of the controversy of whether the short form of the leptin receptor acts as the BBB leptin transporter and how obesity may transform leptin transport is reviewed. Review of these and other topics summarizes in a new appreciation of what leptin may have actually evolved to do and what physiological role leptin resistance may play. © 2021 American Physiological Society. Compr Physiol 11:1-19, 2021." @default.
- W3200065914 created "2021-09-27" @default.
- W3200065914 creator A5054959155 @default.
- W3200065914 date "2021-09-23" @default.
- W3200065914 modified "2023-09-27" @default.
- W3200065914 title "Leptin and the Blood‐Brain Barrier: Curiosities and Controversies" @default.
- W3200065914 cites W1493322662 @default.
- W3200065914 cites W1590709474 @default.
- W3200065914 cites W1619712336 @default.
- W3200065914 cites W1852676216 @default.
- W3200065914 cites W1896220440 @default.
- W3200065914 cites W1941456052 @default.
- W3200065914 cites W1942146052 @default.
- W3200065914 cites W1963690512 @default.
- W3200065914 cites W1964212148 @default.
- W3200065914 cites W1966608496 @default.
- W3200065914 cites W1968055209 @default.
- W3200065914 cites W1968531694 @default.
- W3200065914 cites W1974760551 @default.
- W3200065914 cites W1974838371 @default.
- W3200065914 cites W1976317767 @default.
- W3200065914 cites W1977259783 @default.
- W3200065914 cites W1978028221 @default.
- W3200065914 cites W1978384766 @default.
- W3200065914 cites W1978777200 @default.
- W3200065914 cites W1980664514 @default.
- W3200065914 cites W1981118821 @default.
- W3200065914 cites W1981272224 @default.
- W3200065914 cites W1984881189 @default.
- W3200065914 cites W1985452731 @default.
- W3200065914 cites W1986657180 @default.
- W3200065914 cites W1990958001 @default.
- W3200065914 cites W1991338587 @default.
- W3200065914 cites W1992304191 @default.
- W3200065914 cites W1992328870 @default.
- W3200065914 cites W1992485264 @default.
- W3200065914 cites W1993484591 @default.
- W3200065914 cites W1993537924 @default.
- W3200065914 cites W1994212260 @default.
- W3200065914 cites W1996713062 @default.
- W3200065914 cites W1998525855 @default.
- W3200065914 cites W1998836938 @default.
- W3200065914 cites W2010377986 @default.
- W3200065914 cites W2011997088 @default.
- W3200065914 cites W2012496594 @default.
- W3200065914 cites W2014093920 @default.
- W3200065914 cites W2016261339 @default.
- W3200065914 cites W2016499174 @default.
- W3200065914 cites W2017001601 @default.
- W3200065914 cites W2022584265 @default.
- W3200065914 cites W2022647726 @default.
- W3200065914 cites W2023532283 @default.
- W3200065914 cites W2023830686 @default.
- W3200065914 cites W2027427622 @default.
- W3200065914 cites W2027848835 @default.
- W3200065914 cites W2032777955 @default.
- W3200065914 cites W2035810650 @default.
- W3200065914 cites W2041691732 @default.
- W3200065914 cites W2042535492 @default.
- W3200065914 cites W2042793882 @default.
- W3200065914 cites W2043458888 @default.
- W3200065914 cites W2044682044 @default.
- W3200065914 cites W2045522606 @default.
- W3200065914 cites W2045712842 @default.
- W3200065914 cites W2045851101 @default.
- W3200065914 cites W2046938353 @default.
- W3200065914 cites W2050128775 @default.
- W3200065914 cites W2050662404 @default.
- W3200065914 cites W2051192888 @default.
- W3200065914 cites W2052275096 @default.
- W3200065914 cites W2053446303 @default.
- W3200065914 cites W2054431828 @default.
- W3200065914 cites W2055208283 @default.
- W3200065914 cites W2057883211 @default.
- W3200065914 cites W2059111801 @default.
- W3200065914 cites W2059681129 @default.
- W3200065914 cites W2060060795 @default.
- W3200065914 cites W2062302492 @default.
- W3200065914 cites W2062408600 @default.
- W3200065914 cites W2065503564 @default.
- W3200065914 cites W2065738278 @default.
- W3200065914 cites W2066295481 @default.
- W3200065914 cites W2068673169 @default.
- W3200065914 cites W2073877913 @default.
- W3200065914 cites W2075340869 @default.
- W3200065914 cites W2076996133 @default.
- W3200065914 cites W2077051974 @default.
- W3200065914 cites W2078071267 @default.
- W3200065914 cites W2078482184 @default.
- W3200065914 cites W2078605292 @default.
- W3200065914 cites W2083191706 @default.
- W3200065914 cites W2086139024 @default.
- W3200065914 cites W2087180917 @default.
- W3200065914 cites W2087364210 @default.
- W3200065914 cites W2087402987 @default.
- W3200065914 cites W2088042515 @default.
- W3200065914 cites W2090130376 @default.
- W3200065914 cites W2091087465 @default.