FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200149271> ?p ?o ?g. }

• W3200149271 endingPage "1485" @default.
• W3200149271 startingPage "1485" @default.
• W3200149271 abstract "The reasons behind the poor efficacy of transition metal-based chemotherapies (e.g., cisplatin) or targeted therapies (e.g., histone deacetylase inhibitors, HDACi) on gastric cancer (GC) remain elusive and recent studies suggested that the tumor microenvironment could contribute to the resistance. Hence, our objective was to gain information on the impact of cisplatin and the pan-HDACi SAHA (suberanilohydroxamic acid) on the tumor substructure and microenvironment of GC, by establishing patient-derived xenografts of GC and a combination of ultrasound, immunohistochemistry, and transcriptomics to analyze. The tumors responded partially to SAHA and cisplatin. An ultrasound gave more accurate tumor measures than a caliper. Importantly, an ultrasound allowed a noninvasive real-time access to the tumor substructure, showing differences between cisplatin and SAHA. These differences were confirmed by immunohistochemistry and transcriptomic analyses of the tumor microenvironment, identifying specific cell type signatures and transcription factor activation. For instance, cisplatin induced an “epithelial cell like” signature while SAHA favored a “mesenchymal cell like” one. Altogether, an ultrasound allowed a precise follow-up of the tumor progression while enabling a noninvasive real-time access to the tumor substructure. Combined with transcriptomics, our results underline the different intra-tumoral structural changes caused by both drugs that impact differently on the tumor microenvironment." @default.
• W3200149271 created "2021-09-27" @default.
• W3200149271 creator A5008277545 @default.
• W3200149271 creator A5017806090 @default.
• W3200149271 creator A5025231032 @default.
• W3200149271 creator A5028890097 @default.
• W3200149271 creator A5043790883 @default.
• W3200149271 creator A5043980754 @default.
• W3200149271 creator A5058304156 @default.
• W3200149271 creator A5059278045 @default.
• W3200149271 creator A5066887847 @default.
• W3200149271 creator A5073374992 @default.
• W3200149271 creator A5087236800 @default.
• W3200149271 date "2021-09-16" @default.
• W3200149271 modified "2023-10-15" @default.
• W3200149271 title "Ultrasound and Transcriptomics Identify a Differential Impact of Cisplatin and Histone Deacetylation on Tumor Structure and Microenvironment in a Patient-Derived In Vivo Model of Gastric Cancer" @default.
• W3200149271 cites W1757407923 @default.
• W3200149271 cites W1890643165 @default.
• W3200149271 cites W1969647734 @default.
• W3200149271 cites W1980077995 @default.
• W3200149271 cites W1985481481 @default.
• W3200149271 cites W1990286220 @default.
• W3200149271 cites W1995049733 @default.
• W3200149271 cites W1999833640 @default.
• W3200149271 cites W2000009806 @default.
• W3200149271 cites W2018439279 @default.
• W3200149271 cites W2022301212 @default.
• W3200149271 cites W2039498737 @default.
• W3200149271 cites W2050689676 @default.
• W3200149271 cites W2054013529 @default.
• W3200149271 cites W2066785184 @default.
• W3200149271 cites W2072861589 @default.
• W3200149271 cites W2073827381 @default.
• W3200149271 cites W2075261412 @default.
• W3200149271 cites W2087961523 @default.
• W3200149271 cites W2096031499 @default.
• W3200149271 cites W2097974676 @default.
• W3200149271 cites W2098057936 @default.
• W3200149271 cites W2125109979 @default.
• W3200149271 cites W2125513860 @default.
• W3200149271 cites W2132646345 @default.
• W3200149271 cites W2133176268 @default.
• W3200149271 cites W2134433047 @default.
• W3200149271 cites W2155383651 @default.
• W3200149271 cites W2183034081 @default.
• W3200149271 cites W2256545339 @default.
• W3200149271 cites W2322937685 @default.
• W3200149271 cites W2511667040 @default.
• W3200149271 cites W2512964361 @default.
• W3200149271 cites W2552699553 @default.
• W3200149271 cites W2557402616 @default.
• W3200149271 cites W2559785173 @default.
• W3200149271 cites W2594895774 @default.
• W3200149271 cites W2600505732 @default.
• W3200149271 cites W2605544924 @default.
• W3200149271 cites W2616480517 @default.
• W3200149271 cites W2752397617 @default.
• W3200149271 cites W2766363222 @default.
• W3200149271 cites W2800046513 @default.
• W3200149271 cites W2978506302 @default.
• W3200149271 cites W2980527361 @default.
• W3200149271 cites W2985589940 @default.
• W3200149271 cites W2995471779 @default.
• W3200149271 cites W2997696697 @default.
• W3200149271 cites W3013197036 @default.
• W3200149271 cites W3022152151 @default.
• W3200149271 cites W3027464595 @default.
• W3200149271 cites W3129822877 @default.
• W3200149271 cites W3170943164 @default.
• W3200149271 cites W4243608990 @default.
• W3200149271 doi "https://doi.org/10.3390/pharmaceutics13091485" @default.
• W3200149271 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8467189" @default.
• W3200149271 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34575561" @default.
• W3200149271 hasPublicationYear "2021" @default.
• W3200149271 type Work @default.
• W3200149271 sameAs 3200149271 @default.
• W3200149271 citedByCount "4" @default.
• W3200149271 countsByYear W32001492712022 @default.
• W3200149271 countsByYear W32001492712023 @default.
• W3200149271 crossrefType "journal-article" @default.
• W3200149271 hasAuthorship W3200149271A5008277545 @default.
• W3200149271 hasAuthorship W3200149271A5017806090 @default.
• W3200149271 hasAuthorship W3200149271A5025231032 @default.
• W3200149271 hasAuthorship W3200149271A5028890097 @default.
• W3200149271 hasAuthorship W3200149271A5043790883 @default.
• W3200149271 hasAuthorship W3200149271A5043980754 @default.
• W3200149271 hasAuthorship W3200149271A5058304156 @default.
• W3200149271 hasAuthorship W3200149271A5059278045 @default.
• W3200149271 hasAuthorship W3200149271A5066887847 @default.
• W3200149271 hasAuthorship W3200149271A5073374992 @default.
• W3200149271 hasAuthorship W3200149271A5087236800 @default.
• W3200149271 hasBestOaLocation W32001492711 @default.
• W3200149271 hasConcept C104317684 @default.
• W3200149271 hasConcept C119157956 @default.
• W3200149271 hasConcept C121608353 @default.
• W3200149271 hasConcept C126322002 @default.
• W3200149271 hasConcept C142724271 @default.
• W3200149271 hasConcept C150903083 @default.

• next