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- W3200152783 abstract "The body’s innate and acquired immune systems are critical in responses to a wide spectrum of assaults, including SARS-CoV-2 infection. We identify studies of autoimmunity to support our hypothesis that a high intelligence quotient (IQ) may put children at increased risk for severe COVID-19 sequelae; especially those whose viral load is high and/or who develop multisystem inflammatory syndrome in children (MIS-C). MIS-C is associated with a higher risk of COVID-19 morbidity and death, even in otherwise healthy children. As information and evidence about SARS-CoV-2 infection continue to expand, our hypothesis suggests adding a potentially intriguing piece to the pandemic puzzle for further investigation. Drawing on a select review of published research and case reports, we discuss immune dysregulation in paediatric patients with a high IQ, including post-infection cytokine expression in the myocardium. Further, we provide a review of 27 paediatric (≤19 years; median age 16) cases of severe COVID-19 outcomes, drawn from media sources published between March and September 2020, in which we identify possible evidence of a ‘hyper brain, hyper body’ response to infection. We aver these cases are noteworthy given that paediatric death with COVID-19 disease is remarkably rare, and the estimated prevalence of a high IQ (or giftedness) is only 2% in the general population. These observations warrant prospective and retrospective studies of autoinflammatory markers and mechanisms to elucidate any special psychoneuroimmunological vulnerability in children with a high IQ, as such studies may raise implications for how and when prophylactic medical care is provided to children." @default.
- W3200152783 created "2021-09-27" @default.
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- W3200152783 date "2021-10-01" @default.
- W3200152783 modified "2023-10-18" @default.
- W3200152783 title "High intelligence may exacerbate paediatric inflammatory response to SARS-CoV-2 infection" @default.
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- W3200152783 doi "https://doi.org/10.1016/j.mehy.2021.110677" @default.
- W3200152783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8426136" @default.
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- W3200152783 hasPublicationYear "2021" @default.
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