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- W320018441 abstract "Objective To study the effect of tamoxifen on proliferation of human hepatoellular carcinoma HepG2 cells.Methods The HepG2 cells were treated with tamoxifen at concentrations of 0,7.5,15 and 30 μmol/L.The cells were further cultured for 24,48 and 72 h.The suppression rate of HepG2 cells was determined with MTT.The Smad7 expressive rate of HepG2 cells was examined by immunohistochemistry.Results Tamoxifen inhibited the proliferation of HepG2 cells in a dose-and time-dependent manner.Tamoxifen suppressed expression of Smad7 of HepG2 cells also in a dose-and time-dependent manner.Conclusions Tamoxifen may suppress human hepatocelular carcinoma HepG2 cell proliferation by down-regulating Smad 7 expressions." @default.
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- W320018441 date "2009-01-01" @default.
- W320018441 modified "2023-09-26" @default.
- W320018441 title "Effect of tamoxifen on the Smad 7 expression and proliferation of human hepatocellular carcinoma HepG2 cells." @default.
- W320018441 hasPublicationYear "2009" @default.
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