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• W3200187907 abstract "As cells prepare to divide, they must ensure that enough space is available to assemble the mitotic machinery without perturbing tissue homeostasis. To do so, cells undergo a series of biochemical reactions regulated by cyclin B1-CDK1 that trigger the reorganization of the actomyosin cytoskeleton and ensure the coordination of cytoplasmic and nuclear events. Along with the biochemical events that control mitotic entry, mechanical forces have recently emerged as important players in the regulation of cell cycle events. However, the exact link between mechanical forces and the biochemical events that control mitotic progression remains to be established. Here, we identify a mechanical signal on the nucleus that sets the time for nuclear envelope permeabilization and mitotic entry. This signal relies on nuclear unfolding during the G2-M transition, which activates the stretch-sensitive cPLA2 on the nuclear envelope. This activation upregulates actomyosin contractility, determining the spatiotemporal translocation of cyclin B1 in the nucleus. Our data demonstrate how the mechanosensitive behaviour of cyclin B1 ensures timely and efficient mitotic spindle assembly and prevents chromosomal instability." @default.
• W3200187907 created "2021-09-27" @default.
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• W3200187907 date "2021-09-23" @default.
• W3200187907 modified "2023-10-01" @default.
• W3200187907 title "Mechanosensitive control of mitotic entry" @default.
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• W3200187907 doi "https://doi.org/10.1101/2021.09.23.461473" @default.
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