Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200210852> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W3200210852 abstract "Adenylate Kinase (ADK) catalyzes the reversible interconversion between cytoplasmic nucleotides that is essential for energy homeostasis. We performed several Molecular Dynamics simulations on ADK, containing metal ions Mg+2 and Zn+2. The dynamics of the enzyme were computed on the ion-free structure, and the structures containing individual ions. RMSD and Rg data demonstrate that the coordination of Zn+2 does not significantly affect the overall stability of the enzyme. Decreasing the overall dynamics of the enzyme in the presence of both metal ions was explained by the cooperativity between the stabilizing interactions of metal ions. The high RMSF value of a specific segment in the presence of both ions, demonstrates that a fine balance between the conformational stability and local structural dynamics may be involved in the regulation of the enzyme catalysis. It was also concluded that the orientation of the structural domains is affected by the simultaneous presence of both ions." @default.
- W3200210852 created "2021-09-27" @default.
- W3200210852 creator A5017265254 @default.
- W3200210852 creator A5051565811 @default.
- W3200210852 creator A5078906833 @default.
- W3200210852 date "2020-03-07" @default.
- W3200210852 modified "2023-09-23" @default.
- W3200210852 title "Effect of metal ions on the internal motions of Adenylate Kinase: A Molecular dynamics simulation study" @default.
- W3200210852 doi "https://doi.org/10.22541/au.158359643.35625009" @default.
- W3200210852 hasPublicationYear "2020" @default.
- W3200210852 type Work @default.
- W3200210852 sameAs 3200210852 @default.
- W3200210852 citedByCount "0" @default.
- W3200210852 crossrefType "dataset" @default.
- W3200210852 hasAuthorship W3200210852A5017265254 @default.
- W3200210852 hasAuthorship W3200210852A5051565811 @default.
- W3200210852 hasAuthorship W3200210852A5078906833 @default.
- W3200210852 hasBestOaLocation W32002108521 @default.
- W3200210852 hasConcept C121332964 @default.
- W3200210852 hasConcept C145148216 @default.
- W3200210852 hasConcept C145912823 @default.
- W3200210852 hasConcept C147597530 @default.
- W3200210852 hasConcept C178790620 @default.
- W3200210852 hasConcept C180526460 @default.
- W3200210852 hasConcept C181199279 @default.
- W3200210852 hasConcept C185592680 @default.
- W3200210852 hasConcept C192562407 @default.
- W3200210852 hasConcept C199164860 @default.
- W3200210852 hasConcept C24890656 @default.
- W3200210852 hasConcept C544153396 @default.
- W3200210852 hasConcept C55493867 @default.
- W3200210852 hasConcept C59593255 @default.
- W3200210852 hasConceptScore W3200210852C121332964 @default.
- W3200210852 hasConceptScore W3200210852C145148216 @default.
- W3200210852 hasConceptScore W3200210852C145912823 @default.
- W3200210852 hasConceptScore W3200210852C147597530 @default.
- W3200210852 hasConceptScore W3200210852C178790620 @default.
- W3200210852 hasConceptScore W3200210852C180526460 @default.
- W3200210852 hasConceptScore W3200210852C181199279 @default.
- W3200210852 hasConceptScore W3200210852C185592680 @default.
- W3200210852 hasConceptScore W3200210852C192562407 @default.
- W3200210852 hasConceptScore W3200210852C199164860 @default.
- W3200210852 hasConceptScore W3200210852C24890656 @default.
- W3200210852 hasConceptScore W3200210852C544153396 @default.
- W3200210852 hasConceptScore W3200210852C55493867 @default.
- W3200210852 hasConceptScore W3200210852C59593255 @default.
- W3200210852 hasLocation W32002108521 @default.
- W3200210852 hasOpenAccess W3200210852 @default.
- W3200210852 hasPrimaryLocation W32002108521 @default.
- W3200210852 hasRelatedWork W1998490195 @default.
- W3200210852 hasRelatedWork W2018587054 @default.
- W3200210852 hasRelatedWork W2046594242 @default.
- W3200210852 hasRelatedWork W2061067851 @default.
- W3200210852 hasRelatedWork W2083798919 @default.
- W3200210852 hasRelatedWork W2899084033 @default.
- W3200210852 hasRelatedWork W2981015195 @default.
- W3200210852 hasRelatedWork W3100074996 @default.
- W3200210852 hasRelatedWork W3112407849 @default.
- W3200210852 hasRelatedWork W2110096096 @default.
- W3200210852 isParatext "false" @default.
- W3200210852 isRetracted "false" @default.
- W3200210852 magId "3200210852" @default.
- W3200210852 workType "dataset" @default.