Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200213223> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W3200213223 endingPage "12" @default.
- W3200213223 startingPage "1" @default.
- W3200213223 abstract "A novel series of benzothiazine-3-carboxamide 1,1-dioxide derivatives by modifying the piroxicam scaffold was designed, synthesized, and evaluated as anti-HIV agents. The 1,2-benzothiazine-3-carboxamide 1,1-dioxide scaffold consists of hydroxy and carboxamide groups as a chelating motif to form an interaction with Mg2+ ions within the integrase active site as a target. Most of the compounds displayed encouraging anti-HIV activity in a cell-based assay. Among them, compounds 13d, 13l and 13m were the most potent with EC50 values ranging from 20-25 µM and SI > 26. Docking study of compounds in integrase active site proposed that the mechanism of action of compounds might be through Mg2+ chelation within integrase active site. The lack of severe cytotoxicity and favorable anti-HIV activity of benzothiazine-3-carboxamide 1,1-dioxide derivatives support further modifications to improve the potency." @default.
- W3200213223 created "2021-09-27" @default.
- W3200213223 creator A5021107784 @default.
- W3200213223 creator A5048854498 @default.
- W3200213223 creator A5049655340 @default.
- W3200213223 creator A5052890524 @default.
- W3200213223 creator A5075132123 @default.
- W3200213223 date "2021-01-01" @default.
- W3200213223 modified "2023-09-23" @default.
- W3200213223 title "Design, Synthesis, Docking Study and Biological Evaluation of 4-Hydroxy-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide Derivatives as Anti-HIV Agents." @default.
- W3200213223 doi "https://doi.org/10.22037/ijpr.2020.114153.14695" @default.
- W3200213223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34903964" @default.
- W3200213223 hasPublicationYear "2021" @default.
- W3200213223 type Work @default.
- W3200213223 sameAs 3200213223 @default.
- W3200213223 citedByCount "0" @default.
- W3200213223 crossrefType "journal-article" @default.
- W3200213223 hasAuthorship W3200213223A5021107784 @default.
- W3200213223 hasAuthorship W3200213223A5048854498 @default.
- W3200213223 hasAuthorship W3200213223A5049655340 @default.
- W3200213223 hasAuthorship W3200213223A5052890524 @default.
- W3200213223 hasAuthorship W3200213223A5075132123 @default.
- W3200213223 hasConcept C104317684 @default.
- W3200213223 hasConcept C142462285 @default.
- W3200213223 hasConcept C14430832 @default.
- W3200213223 hasConcept C155647269 @default.
- W3200213223 hasConcept C159110408 @default.
- W3200213223 hasConcept C178790620 @default.
- W3200213223 hasConcept C185592680 @default.
- W3200213223 hasConcept C197404232 @default.
- W3200213223 hasConcept C202751555 @default.
- W3200213223 hasConcept C203014093 @default.
- W3200213223 hasConcept C21951064 @default.
- W3200213223 hasConcept C2777302000 @default.
- W3200213223 hasConcept C2778327999 @default.
- W3200213223 hasConcept C2780159532 @default.
- W3200213223 hasConcept C2993143319 @default.
- W3200213223 hasConcept C3013748606 @default.
- W3200213223 hasConcept C41685203 @default.
- W3200213223 hasConcept C55493867 @default.
- W3200213223 hasConcept C57992300 @default.
- W3200213223 hasConcept C71240020 @default.
- W3200213223 hasConcept C71924100 @default.
- W3200213223 hasConcept C86803240 @default.
- W3200213223 hasConcept C98274493 @default.
- W3200213223 hasConceptScore W3200213223C104317684 @default.
- W3200213223 hasConceptScore W3200213223C142462285 @default.
- W3200213223 hasConceptScore W3200213223C14430832 @default.
- W3200213223 hasConceptScore W3200213223C155647269 @default.
- W3200213223 hasConceptScore W3200213223C159110408 @default.
- W3200213223 hasConceptScore W3200213223C178790620 @default.
- W3200213223 hasConceptScore W3200213223C185592680 @default.
- W3200213223 hasConceptScore W3200213223C197404232 @default.
- W3200213223 hasConceptScore W3200213223C202751555 @default.
- W3200213223 hasConceptScore W3200213223C203014093 @default.
- W3200213223 hasConceptScore W3200213223C21951064 @default.
- W3200213223 hasConceptScore W3200213223C2777302000 @default.
- W3200213223 hasConceptScore W3200213223C2778327999 @default.
- W3200213223 hasConceptScore W3200213223C2780159532 @default.
- W3200213223 hasConceptScore W3200213223C2993143319 @default.
- W3200213223 hasConceptScore W3200213223C3013748606 @default.
- W3200213223 hasConceptScore W3200213223C41685203 @default.
- W3200213223 hasConceptScore W3200213223C55493867 @default.
- W3200213223 hasConceptScore W3200213223C57992300 @default.
- W3200213223 hasConceptScore W3200213223C71240020 @default.
- W3200213223 hasConceptScore W3200213223C71924100 @default.
- W3200213223 hasConceptScore W3200213223C86803240 @default.
- W3200213223 hasConceptScore W3200213223C98274493 @default.
- W3200213223 hasIssue "3" @default.
- W3200213223 hasLocation W32002132231 @default.
- W3200213223 hasOpenAccess W3200213223 @default.
- W3200213223 hasPrimaryLocation W32002132231 @default.
- W3200213223 hasRelatedWork W10445348 @default.
- W3200213223 hasRelatedWork W15786899 @default.
- W3200213223 hasRelatedWork W28830211 @default.
- W3200213223 hasRelatedWork W32389250 @default.
- W3200213223 hasRelatedWork W35520510 @default.
- W3200213223 hasRelatedWork W37387383 @default.
- W3200213223 hasRelatedWork W4810758 @default.
- W3200213223 hasRelatedWork W5586144 @default.
- W3200213223 hasRelatedWork W10440690 @default.
- W3200213223 hasRelatedWork W4503287 @default.
- W3200213223 hasVolume "20" @default.
- W3200213223 isParatext "false" @default.
- W3200213223 isRetracted "false" @default.
- W3200213223 magId "3200213223" @default.
- W3200213223 workType "article" @default.