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- W3200238440 endingPage "119" @default.
- W3200238440 startingPage "89" @default.
- W3200238440 abstract "Nearly two million cases of cutaneous squamous cell carcinoma (cSCC) are diagnosed every year in the United States alone. cSCC is notable for both its prevalence and its propensity for invasion and metastasis. For many patients, surgery is curative. However, patients experiencing immunosuppression or recurrent, advanced, and metastatic disease still face limited therapeutic options and significant mortality. cSCC forms after decades of sun exposure and possesses the highest known mutation rate of all cancers. This mutational burden complicates efforts to identify the primary factors driving cSCC initiation and progression, which in turn hinders the development of targeted therapeutics. In this review, we summarize the mutations and alterations that have been observed in patients' cSCC tumors, affecting signaling pathways, transcriptional regulators, and the microenvironment. We also highlight novel therapeutic opportunities in development and clinical trials." @default.
- W3200238440 created "2021-09-27" @default.
- W3200238440 creator A5048407318 @default.
- W3200238440 creator A5067946684 @default.
- W3200238440 date "2021-09-22" @default.
- W3200238440 modified "2023-10-02" @default.
- W3200238440 title "Oh, the Mutations You’ll Acquire! A Systematic Overview of Cutaneous Squamous Cell Carcinoma" @default.
- W3200238440 cites W1096081229 @default.
- W3200238440 cites W1482750262 @default.
- W3200238440 cites W1512368430 @default.
- W3200238440 cites W1530239928 @default.
- W3200238440 cites W1572243330 @default.
- W3200238440 cites W1803984755 @default.
- W3200238440 cites W1852538637 @default.
- W3200238440 cites W1956871134 @default.
- W3200238440 cites W1964650964 @default.
- W3200238440 cites W1971559058 @default.
- W3200238440 cites W1971819775 @default.
- W3200238440 cites W1973546144 @default.
- W3200238440 cites W1975100017 @default.
- W3200238440 cites W1976056452 @default.
- W3200238440 cites W1979627083 @default.
- W3200238440 cites W1984250082 @default.
- W3200238440 cites W1988958344 @default.
- W3200238440 cites W1991275453 @default.
- W3200238440 cites W1992071574 @default.
- W3200238440 cites W1994992191 @default.
- W3200238440 cites W1995004385 @default.
- W3200238440 cites W1996094589 @default.
- W3200238440 cites W1996583578 @default.
- W3200238440 cites W1997466583 @default.
- W3200238440 cites W1997744869 @default.
- W3200238440 cites W2002211092 @default.
- W3200238440 cites W2005013681 @default.
- W3200238440 cites W2005062632 @default.
- W3200238440 cites W2006216648 @default.
- W3200238440 cites W2010718183 @default.
- W3200238440 cites W2011493192 @default.
- W3200238440 cites W2017593987 @default.
- W3200238440 cites W2019220228 @default.
- W3200238440 cites W2020459118 @default.
- W3200238440 cites W2021837487 @default.
- W3200238440 cites W2032200487 @default.
- W3200238440 cites W2032344783 @default.
- W3200238440 cites W2034849370 @default.
- W3200238440 cites W2037646632 @default.
- W3200238440 cites W2037838528 @default.
- W3200238440 cites W2038938990 @default.
- W3200238440 cites W2045639763 @default.
- W3200238440 cites W2050887031 @default.
- W3200238440 cites W2051992359 @default.
- W3200238440 cites W2052059673 @default.
- W3200238440 cites W2052064875 @default.
- W3200238440 cites W2052678745 @default.
- W3200238440 cites W2053366738 @default.
- W3200238440 cites W2057587445 @default.
- W3200238440 cites W2059179724 @default.
- W3200238440 cites W2064238367 @default.
- W3200238440 cites W2066271914 @default.
- W3200238440 cites W2066500792 @default.
- W3200238440 cites W2069144282 @default.
- W3200238440 cites W2070081201 @default.
- W3200238440 cites W2070471604 @default.
- W3200238440 cites W2071311021 @default.
- W3200238440 cites W2072896158 @default.
- W3200238440 cites W2077989199 @default.
- W3200238440 cites W2078830973 @default.
- W3200238440 cites W2079216025 @default.
- W3200238440 cites W2080698029 @default.
- W3200238440 cites W2081588299 @default.
- W3200238440 cites W2083124053 @default.
- W3200238440 cites W2084753863 @default.
- W3200238440 cites W2089110618 @default.
- W3200238440 cites W2093208648 @default.
- W3200238440 cites W2093745735 @default.
- W3200238440 cites W2099034576 @default.
- W3200238440 cites W2101044289 @default.
- W3200238440 cites W2101183670 @default.
- W3200238440 cites W2101568666 @default.
- W3200238440 cites W2102929941 @default.
- W3200238440 cites W2104278772 @default.
- W3200238440 cites W2104493973 @default.
- W3200238440 cites W2107541885 @default.
- W3200238440 cites W2107570915 @default.
- W3200238440 cites W2112267492 @default.
- W3200238440 cites W2112765713 @default.
- W3200238440 cites W2114248398 @default.
- W3200238440 cites W2117882071 @default.
- W3200238440 cites W2118996059 @default.
- W3200238440 cites W2119388029 @default.
- W3200238440 cites W2119547186 @default.
- W3200238440 cites W2119956454 @default.
- W3200238440 cites W2120246444 @default.
- W3200238440 cites W2124813239 @default.
- W3200238440 cites W2126490929 @default.
- W3200238440 cites W2130227833 @default.
- W3200238440 cites W2131757723 @default.
- W3200238440 cites W2133598334 @default.