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- W3200250339 abstract "Capsule endoscopy (SBCE) has developed a relevant role in patients with established Crohn's Disease (CD). However, evaluation of the impact in clinical management has been scarce.To evaluate therapeutic impact of SBCE in an 11-year real-life cohort of known CD patients.Retrospective single center study including all patients with established CD submitted to SBCE procedure from 01/01/2008 to 31/12/2019. Patency capsule was used in selected patients. Small bowel mucosal inflammation was quantified using Lewis score. Therapeutic impact was defined as a change in CD-related treatment recommended based on SBCE results. Patients were assigned to four groups regarding SBCE indication: staging, flare, post-op and remission.From the 432 SBCE performed 87.5% were conclusive. Active disease was present in 63.7 of patients; 41.6% mild inflammation and 21.9% moderate-to-severe activity. A change of management was guided by SBCE in 51.3% of procedures: 199 (46.1%) escalation and 23 (5.3%) de-escalation, with significant changes in all groups. Escalation increased with disease activity: 57.8% in mild and 89.5% in moderate-to-severe disease. De-escalation was conducted in 13.9% procedures with mucosal healing and 1.1% with mild disease.SBCE is a useful tool for guiding therapeutic management in CD patients both for treatment escalation and de-escalation." @default.
- W3200250339 created "2021-09-27" @default.
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- W3200250339 date "2022-01-01" @default.
- W3200250339 modified "2023-10-12" @default.
- W3200250339 title "Does capsule endoscopy impact clinical management in established Crohn's disease?" @default.
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- W3200250339 doi "https://doi.org/10.1016/j.dld.2021.08.014" @default.
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