FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200284954> ?p ?o ?g. }

• W3200284954 endingPage "152963" @default.
• W3200284954 startingPage "152963" @default.
• W3200284954 abstract "As a promising class of bioactive marine pyrrole alkaloids, lamellarins reportedly act on multiple targets to suppress the vitality of various cancer cell lines. Nevertheless, an in-depth understanding of the molecular mechanisms governing their cytotoxicity is still in demand. Here we report that while activating intrinsic apoptosis, up to 5 μM of lamellarins and their lactam-containing analogs, azalamellarins, also induced mitochondrial stress responses and autophagy in HeLa cervical cancer cells. Detailed characterization of the mitochondria in the treated cells revealed shifted abundance of the two optic atrophy protein 1 (Opa1) isoforms, disturbed morphology, and dissipated membrane potential, leading to PTEN-induced kinase-1 (PINK1) and microtubule-associated protein 1 light chain 3-II (LC3-II) accumulation as a molecular signature of mitophagy. Furthermore, an acute treatment with lamellarins also modulated cellular autophagy flux as evidenced by elevated LC3-II levels, LC3 puncta formation, and p62 degradation. Surprisingly, clustered regularly interspaced short palindromic repeats (CRISPR)-based suppression of autophagy transiently affected the number of apoptotic cells induced by these compounds. Our findings illustrate the potential of these alkaloids for further development into prospective anti-cancer agents." @default.
• W3200284954 created "2021-09-27" @default.
• W3200284954 creator A5042850503 @default.
• W3200284954 creator A5049744396 @default.
• W3200284954 creator A5053616831 @default.
• W3200284954 creator A5059353232 @default.
• W3200284954 creator A5081545614 @default.
• W3200284954 creator A5089680739 @default.
• W3200284954 date "2021-10-01" @default.
• W3200284954 modified "2023-09-25" @default.
• W3200284954 title "Roles of autophagy in relation to mitochondrial stress responses of HeLa cells to lamellarin cytotoxicity" @default.
• W3200284954 cites W1496351322 @default.
• W3200284954 cites W1748363949 @default.
• W3200284954 cites W1964420304 @default.
• W3200284954 cites W1977659151 @default.
• W3200284954 cites W1977709885 @default.
• W3200284954 cites W1989351238 @default.
• W3200284954 cites W1997177313 @default.
• W3200284954 cites W2011673428 @default.
• W3200284954 cites W2023786663 @default.
• W3200284954 cites W2025665129 @default.
• W3200284954 cites W2032234589 @default.
• W3200284954 cites W2032937743 @default.
• W3200284954 cites W2037064466 @default.
• W3200284954 cites W2056923697 @default.
• W3200284954 cites W2057030511 @default.
• W3200284954 cites W2076769172 @default.
• W3200284954 cites W2077704652 @default.
• W3200284954 cites W2079351077 @default.
• W3200284954 cites W2096348285 @default.
• W3200284954 cites W2097586473 @default.
• W3200284954 cites W2101228747 @default.
• W3200284954 cites W2104162873 @default.
• W3200284954 cites W2108326484 @default.
• W3200284954 cites W2111626525 @default.
• W3200284954 cites W2116562304 @default.
• W3200284954 cites W2116836791 @default.
• W3200284954 cites W2121077787 @default.
• W3200284954 cites W2127377435 @default.
• W3200284954 cites W2130687851 @default.
• W3200284954 cites W2131415852 @default.
• W3200284954 cites W2133575920 @default.
• W3200284954 cites W2143410022 @default.
• W3200284954 cites W2148749720 @default.
• W3200284954 cites W2153850374 @default.
• W3200284954 cites W2167656141 @default.
• W3200284954 cites W2399267833 @default.
• W3200284954 cites W2408954743 @default.
• W3200284954 cites W2480725775 @default.
• W3200284954 cites W2524192596 @default.
• W3200284954 cites W2558729727 @default.
• W3200284954 cites W2729738977 @default.
• W3200284954 cites W2742558281 @default.
• W3200284954 cites W2773298122 @default.
• W3200284954 cites W2899241243 @default.
• W3200284954 cites W2936614919 @default.
• W3200284954 cites W2980622391 @default.
• W3200284954 cites W3008000594 @default.
• W3200284954 cites W3012638502 @default.
• W3200284954 cites W3042533317 @default.
• W3200284954 cites W611331246 @default.
• W3200284954 doi "https://doi.org/10.1016/j.tox.2021.152963" @default.
• W3200284954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34560126" @default.
• W3200284954 hasPublicationYear "2021" @default.
• W3200284954 type Work @default.
• W3200284954 sameAs 3200284954 @default.
• W3200284954 citedByCount "5" @default.
• W3200284954 countsByYear W32002849542022 @default.
• W3200284954 countsByYear W32002849542023 @default.
• W3200284954 crossrefType "journal-article" @default.
• W3200284954 hasAuthorship W3200284954A5042850503 @default.
• W3200284954 hasAuthorship W3200284954A5049744396 @default.
• W3200284954 hasAuthorship W3200284954A5053616831 @default.
• W3200284954 hasAuthorship W3200284954A5059353232 @default.
• W3200284954 hasAuthorship W3200284954A5081545614 @default.
• W3200284954 hasAuthorship W3200284954A5089680739 @default.
• W3200284954 hasConcept C109316439 @default.
• W3200284954 hasConcept C121608353 @default.
• W3200284954 hasConcept C1491633281 @default.
• W3200284954 hasConcept C190283241 @default.
• W3200284954 hasConcept C202751555 @default.
• W3200284954 hasConcept C203522944 @default.
• W3200284954 hasConcept C2776804853 @default.
• W3200284954 hasConcept C2777366897 @default.
• W3200284954 hasConcept C2779324830 @default.
• W3200284954 hasConcept C28859421 @default.
• W3200284954 hasConcept C31573885 @default.
• W3200284954 hasConcept C54355233 @default.
• W3200284954 hasConcept C55493867 @default.
• W3200284954 hasConcept C86803240 @default.
• W3200284954 hasConcept C95444343 @default.
• W3200284954 hasConcept C96232424 @default.
• W3200284954 hasConceptScore W3200284954C109316439 @default.
• W3200284954 hasConceptScore W3200284954C121608353 @default.
• W3200284954 hasConceptScore W3200284954C1491633281 @default.
• W3200284954 hasConceptScore W3200284954C190283241 @default.
• W3200284954 hasConceptScore W3200284954C202751555 @default.
• W3200284954 hasConceptScore W3200284954C203522944 @default.

• next