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- W3200293216 abstract "Abstract The negative association between Alzheimer’s disease (AD) and cancer suggests that susceptibility to one disease may protect against the other. When biological mechanisms of AD and cancer and relationship between them are understood, the unsolved problem of both diseases which still touches the growing human population could be overcome. Actual information about biological mechanisms and common risk factors such as chronic inflammation, age-related metabolic deregulation, and family history is presented here. Common signaling pathways, e.g., p53, Wnt, role of Pin1, and microRNA, are discussed as well. Much attention is also paid to the potential impact of chronic viral, bacterial, and fungal infections that are responsible for the inflammatory pathway in AD and also play a key role to cancer development. New data about common mechanisms in etiopathology of cancer and neurological diseases suggests new therapeutic strategies. Among them, the use of nilotinib, tyrosine kinase inhibitor, protein kinase C, and bexarotene is the most promising." @default.
- W3200293216 created "2021-09-27" @default.
- W3200293216 creator A5010111614 @default.
- W3200293216 creator A5026729333 @default.
- W3200293216 creator A5046091756 @default.
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- W3200293216 creator A5055473727 @default.
- W3200293216 creator A5059258193 @default.
- W3200293216 creator A5062059974 @default.
- W3200293216 date "2021-09-14" @default.
- W3200293216 modified "2023-10-15" @default.
- W3200293216 title "Inverse Correlation Between Alzheimer’s Disease and Cancer: Short Overview" @default.
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