FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200296062> ?p ?o ?g. }

• W3200296062 endingPage "25" @default.
• W3200296062 startingPage "19" @default.
• W3200296062 abstract "Only a few studies are available on dose-related effects of sacubitril/valsartan (angiotensin receptor neprilysin inhibition (ARNI)) in real-life patients with heart failure and reduced ejection fraction (HFrEF). We sought to investigate clinical and functional effects in real-life HFrEF patients receiving ARNI at a different cumulative dose.This was an observational study in consecutive outpatients admitted for HFrEF from October 2017 to June 2019. The PARADIGM criteria were needed for enrolment. ARNI was uptitrated according to blood pressure, drug tolerability, renal function and kaliemia. At least 10-month follow-up was required in each patient. Clinical assessment, Kansas City Cardiomyopathy Questionnaire (KCCQ) score, 6-min walk test and strain echocardiography were performed in each patient on a regular basis during the observational period. At the end of the study, patients were divided into two groups based on the median yearly dose of the ARNI medication.A total of 90 patients, 64 ± 11 years, 82% males, were enrolled. The cut-off dose was established in 75 mg BID, and the study population was divided into group A (≤ 75 mg), 52 patients (58%), and group B (> 75 mg), 38 patients (42%). The follow-up duration was 12 months (range 11-13). NYHA class, KCCQ score and 6MWT performance ameliorated in both groups, with a quicker time to benefit in group B. The proportion of patients walking > 350 m increased from 21 to 58% in group A (p < 0.001), and from 29 to 82% in group B (p < 0.001). A positive effect was also disclosed in the left ventricular remodelling, strain deformation and diastolic function.One-year ARNI treatment was effective in our real-life HFrEF patient population, leading to clinical and functional improvement in both study groups, slightly greater and with a shorter time to benefit in group B." @default.
• W3200296062 created "2021-09-27" @default.
• W3200296062 creator A5000908629 @default.
• W3200296062 creator A5009698800 @default.
• W3200296062 creator A5014426314 @default.
• W3200296062 creator A5024025041 @default.
• W3200296062 creator A5024275708 @default.
• W3200296062 creator A5031271747 @default.
• W3200296062 creator A5040365880 @default.
• W3200296062 creator A5058833143 @default.
• W3200296062 date "2021-09-23" @default.
• W3200296062 modified "2023-10-18" @default.
• W3200296062 title "Low- vs high-dose ARNI effects on clinical status, exercise performance and cardiac function in real-life HFrEF patients" @default.
• W3200296062 cites W1787714973 @default.
• W3200296062 cites W1969495161 @default.
• W3200296062 cites W2113698123 @default.
• W3200296062 cites W2120312774 @default.
• W3200296062 cites W2140044661 @default.
• W3200296062 cites W2380447421 @default.
• W3200296062 cites W2413467082 @default.
• W3200296062 cites W2609605008 @default.
• W3200296062 cites W2739124482 @default.
• W3200296062 cites W2773839907 @default.
• W3200296062 cites W2790346830 @default.
• W3200296062 cites W2791640892 @default.
• W3200296062 cites W2808857783 @default.
• W3200296062 cites W2903072644 @default.
• W3200296062 cites W2903958160 @default.
• W3200296062 cites W2918354055 @default.
• W3200296062 cites W2938564873 @default.
• W3200296062 cites W2945964784 @default.
• W3200296062 cites W2954586029 @default.
• W3200296062 cites W2975408293 @default.
• W3200296062 cites W2982651646 @default.
• W3200296062 cites W2984385307 @default.
• W3200296062 cites W3006700710 @default.
• W3200296062 cites W3011755245 @default.
• W3200296062 cites W3013551061 @default.
• W3200296062 cites W3035255089 @default.
• W3200296062 cites W3035293113 @default.
• W3200296062 cites W3037436886 @default.
• W3200296062 cites W3048483202 @default.
• W3200296062 cites W3109417737 @default.
• W3200296062 cites W3122972572 @default.
• W3200296062 cites W3177217938 @default.
• W3200296062 cites W3192852503 @default.
• W3200296062 cites W4238907867 @default.
• W3200296062 cites W4245666729 @default.
• W3200296062 doi "https://doi.org/10.1007/s00228-021-03210-0" @default.
• W3200296062 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8458558" @default.
• W3200296062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34554274" @default.
• W3200296062 hasPublicationYear "2021" @default.
• W3200296062 type Work @default.
• W3200296062 sameAs 3200296062 @default.
• W3200296062 citedByCount "7" @default.
• W3200296062 countsByYear W32002960622022 @default.
• W3200296062 countsByYear W32002960622023 @default.
• W3200296062 crossrefType "journal-article" @default.
• W3200296062 hasAuthorship W3200296062A5000908629 @default.
• W3200296062 hasAuthorship W3200296062A5009698800 @default.
• W3200296062 hasAuthorship W3200296062A5014426314 @default.
• W3200296062 hasAuthorship W3200296062A5024025041 @default.
• W3200296062 hasAuthorship W3200296062A5024275708 @default.
• W3200296062 hasAuthorship W3200296062A5031271747 @default.
• W3200296062 hasAuthorship W3200296062A5040365880 @default.
• W3200296062 hasAuthorship W3200296062A5058833143 @default.
• W3200296062 hasBestOaLocation W32002960621 @default.
• W3200296062 hasConcept C111566952 @default.
• W3200296062 hasConcept C126322002 @default.
• W3200296062 hasConcept C164705383 @default.
• W3200296062 hasConcept C197934379 @default.
• W3200296062 hasConcept C23131810 @default.
• W3200296062 hasConcept C2775999527 @default.
• W3200296062 hasConcept C2776754050 @default.
• W3200296062 hasConcept C2777288759 @default.
• W3200296062 hasConcept C2777387769 @default.
• W3200296062 hasConcept C2778198053 @default.
• W3200296062 hasConcept C2778375690 @default.
• W3200296062 hasConcept C2908647359 @default.
• W3200296062 hasConcept C71924100 @default.
• W3200296062 hasConcept C78085059 @default.
• W3200296062 hasConcept C84393581 @default.
• W3200296062 hasConcept C99454951 @default.
• W3200296062 hasConceptScore W3200296062C111566952 @default.
• W3200296062 hasConceptScore W3200296062C126322002 @default.
• W3200296062 hasConceptScore W3200296062C164705383 @default.
• W3200296062 hasConceptScore W3200296062C197934379 @default.
• W3200296062 hasConceptScore W3200296062C23131810 @default.
• W3200296062 hasConceptScore W3200296062C2775999527 @default.
• W3200296062 hasConceptScore W3200296062C2776754050 @default.
• W3200296062 hasConceptScore W3200296062C2777288759 @default.
• W3200296062 hasConceptScore W3200296062C2777387769 @default.
• W3200296062 hasConceptScore W3200296062C2778198053 @default.
• W3200296062 hasConceptScore W3200296062C2778375690 @default.
• W3200296062 hasConceptScore W3200296062C2908647359 @default.
• W3200296062 hasConceptScore W3200296062C71924100 @default.
• W3200296062 hasConceptScore W3200296062C78085059 @default.
• W3200296062 hasConceptScore W3200296062C84393581 @default.

• next