FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200308086> ?p ?o ?g. }

• W3200308086 abstract "Abstract Background Dietary 2-hydroxy-4-methylselenobutanoic acid (HMSeBA) supplementation can exert antioxidant effects in poultry, pigs and weaned pigs. However, it is unknown whether HMSeBA could improve the development of follicle by anti-oxidize effects in gilt. This study was conducted to evaluate the effects of dietary HMSeBA supplementation on the follicle development in gilt. A total of 36 gilts were randomly fed the control diet (CON, negative control), Na 2 SeO 3 diet containing 0.3 mg Se/kg (positive control) or the HMSeBA diet containing 0.3 mg Se/kg from weaning to the 19th day after the second estrus. In another study, the effect of HMSeBA on the cells viability, proliferation, release of 17βestradiol (E 2 ) and antioxidant capacity were investigated in the mouse ovarian granulosa cells in vitro. Results Results showed that HMSeBA group increased the average daily body weight gain (ADG) and decreased the ratio of feed: gain during day 120 to 176 in gilts ( P < 0.05). The selenium (HMSeBA and Na 2 SeO 3 ) increased the weight of uterine at the third estrus. There was no effect of HMSeBA on the number of large follicles (diameter >5mm), but HMSeBA decreased the gene expression of growth differentiation factor-9 ( GDF-9 ) and bone morphogenetic protein-15 ( BMP-15 ) in cumulus-oocyte complexes (COCs). HMSeBA group increased the total selenium content in serum ( P < 0.05) and liver ( P < 0.01) and tended to increase the total selenium content in ovary ( P = 0.08). HMSeBA group decreased the malondialdehyde (MDA) concentration in the serum, liver and ovary ( P < 0.05), increased the total antioxidant capacity (T-AOC) in the liver, thioredoxin reductase (TrxR) in the ovary ( P < 0.05) and increased the activity of GPx in the serum, liver and ovary ( P < 0.05). Na 2 SeO 3 supplementation decreased MDA and increased the T-AOC in liver, increased the T-SOD and TrxR in the ovary compared with control. At the transcription level, HMSeBA group increased the glutathione peroxidase 2 ( GPx2 ) and TrxR1 ( P < 0.05) expression in the liver, and increased the GPx1 expression ( P < 0.05) in the ovary of gilts compared with Na 2 SeO 3 treatment. Besides, HMSeBA group increased the expressions of superoxide dismutase 1 ( SOD1 ) and Thioredoxin l ( Trx1 ) in the liver. In vitro experiment, HMSeBA improved granulosa cells’ proliferation and E 2 secretion ( P < 0.05). HMSeBA and Na 2 SeO 3 both increased the T-AOC and decreased MDA in granulosa cells in vitro . Meanwhile, HMSeBA increased T-SOD, GPx, glutathione reductase (GR) and TrxR activity in granulosa cells in vitro . In addition, HMSeBA up-regulated SOD2 and GPx1 gene expression in the granulosa cells in vitro . Conclusion These results demonstrate directly, HMSeBA was more conducive to absorption and storage of selenium in the liver and ovary in gilt, and beneficial to exert the effect of HMSeBA on the antioxidant function in the liver and ovary of gilt. Moreover, HMSeBA has stronger antioxidant capacity in granular cells in vitro , which is more conducive to promoting follicle development. Therefore, the new type of organic selenium, HMSeBA, could be potentially useful for the control of reproductive processes in gilt." @default.
• W3200308086 created "2021-09-27" @default.
• W3200308086 creator A5010612920 @default.
• W3200308086 creator A5016049539 @default.
• W3200308086 creator A5027046605 @default.
• W3200308086 creator A5029587145 @default.
• W3200308086 creator A5029650048 @default.
• W3200308086 creator A5032457463 @default.
• W3200308086 creator A5046663841 @default.
• W3200308086 creator A5048025320 @default.
• W3200308086 creator A5060742506 @default.
• W3200308086 creator A5062701102 @default.
• W3200308086 creator A5065989028 @default.
• W3200308086 creator A5068306950 @default.
• W3200308086 creator A5074889378 @default.
• W3200308086 creator A5080816201 @default.
• W3200308086 creator A5085691179 @default.
• W3200308086 creator A5086440624 @default.
• W3200308086 creator A5086918686 @default.
• W3200308086 date "2021-09-14" @default.
• W3200308086 modified "2023-09-27" @default.
• W3200308086 title "2-Hydroxy-4-Methylselenobutanoic Acid (HMSeBA) Promote Follicle Development By Antioxidant Pathway in Gilts" @default.
• W3200308086 doi "https://doi.org/10.21203/rs.3.rs-850421/v1" @default.
• W3200308086 hasPublicationYear "2021" @default.
• W3200308086 type Work @default.
• W3200308086 sameAs 3200308086 @default.
• W3200308086 citedByCount "0" @default.
• W3200308086 crossrefType "posted-content" @default.
• W3200308086 hasAuthorship W3200308086A5010612920 @default.
• W3200308086 hasAuthorship W3200308086A5016049539 @default.
• W3200308086 hasAuthorship W3200308086A5027046605 @default.
• W3200308086 hasAuthorship W3200308086A5029587145 @default.
• W3200308086 hasAuthorship W3200308086A5029650048 @default.
• W3200308086 hasAuthorship W3200308086A5032457463 @default.
• W3200308086 hasAuthorship W3200308086A5046663841 @default.
• W3200308086 hasAuthorship W3200308086A5048025320 @default.
• W3200308086 hasAuthorship W3200308086A5060742506 @default.
• W3200308086 hasAuthorship W3200308086A5062701102 @default.
• W3200308086 hasAuthorship W3200308086A5065989028 @default.
• W3200308086 hasAuthorship W3200308086A5068306950 @default.
• W3200308086 hasAuthorship W3200308086A5074889378 @default.
• W3200308086 hasAuthorship W3200308086A5080816201 @default.
• W3200308086 hasAuthorship W3200308086A5085691179 @default.
• W3200308086 hasAuthorship W3200308086A5086440624 @default.
• W3200308086 hasAuthorship W3200308086A5086918686 @default.
• W3200308086 hasBestOaLocation W32003080861 @default.
• W3200308086 hasConcept C102570824 @default.
• W3200308086 hasConcept C104317684 @default.
• W3200308086 hasConcept C126322002 @default.
• W3200308086 hasConcept C134018914 @default.
• W3200308086 hasConcept C140793950 @default.
• W3200308086 hasConcept C16685009 @default.
• W3200308086 hasConcept C178790620 @default.
• W3200308086 hasConcept C185592680 @default.
• W3200308086 hasConcept C1998276 @default.
• W3200308086 hasConcept C2778004101 @default.
• W3200308086 hasConcept C2778324911 @default.
• W3200308086 hasConcept C2780655333 @default.
• W3200308086 hasConcept C5512455 @default.
• W3200308086 hasConcept C553756173 @default.
• W3200308086 hasConcept C55493867 @default.
• W3200308086 hasConcept C71924100 @default.
• W3200308086 hasConcept C86803240 @default.
• W3200308086 hasConcept C87073359 @default.
• W3200308086 hasConceptScore W3200308086C102570824 @default.
• W3200308086 hasConceptScore W3200308086C104317684 @default.
• W3200308086 hasConceptScore W3200308086C126322002 @default.
• W3200308086 hasConceptScore W3200308086C134018914 @default.
• W3200308086 hasConceptScore W3200308086C140793950 @default.
• W3200308086 hasConceptScore W3200308086C16685009 @default.
• W3200308086 hasConceptScore W3200308086C178790620 @default.
• W3200308086 hasConceptScore W3200308086C185592680 @default.
• W3200308086 hasConceptScore W3200308086C1998276 @default.
• W3200308086 hasConceptScore W3200308086C2778004101 @default.
• W3200308086 hasConceptScore W3200308086C2778324911 @default.
• W3200308086 hasConceptScore W3200308086C2780655333 @default.
• W3200308086 hasConceptScore W3200308086C5512455 @default.
• W3200308086 hasConceptScore W3200308086C553756173 @default.
• W3200308086 hasConceptScore W3200308086C55493867 @default.
• W3200308086 hasConceptScore W3200308086C71924100 @default.
• W3200308086 hasConceptScore W3200308086C86803240 @default.
• W3200308086 hasConceptScore W3200308086C87073359 @default.
• W3200308086 hasLocation W32003080861 @default.
• W3200308086 hasOpenAccess W3200308086 @default.
• W3200308086 hasPrimaryLocation W32003080861 @default.
• W3200308086 hasRelatedWork W1989139176 @default.
• W3200308086 hasRelatedWork W1995631766 @default.
• W3200308086 hasRelatedWork W2023197167 @default.
• W3200308086 hasRelatedWork W2054536952 @default.
• W3200308086 hasRelatedWork W2118981894 @default.
• W3200308086 hasRelatedWork W2172100709 @default.
• W3200308086 hasRelatedWork W2370402144 @default.
• W3200308086 hasRelatedWork W2466520145 @default.
• W3200308086 hasRelatedWork W2809063501 @default.
• W3200308086 hasRelatedWork W4200378300 @default.
• W3200308086 isParatext "false" @default.
• W3200308086 isRetracted "false" @default.
• W3200308086 magId "3200308086" @default.
• W3200308086 workType "article" @default.