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- W32003125 abstract "Les mycobactéries atypiques et l’Aspergillus sont des agents opportunistes responsables de pathologies pulmonaires sévères dont la survenue est favorisée par l’existence d’une bronchopneumopathie pulmonaire chronique obstructive (BPCO) et de facteurs d’immunodépression relative. Nous rapportons les observations de deux patients éthyliques chroniques porteurs d’une BPCO post-tabagique emphysémateuse, ayant développé une aspergillose pulmonaire chronique dans les suites d’une infection pulmonaire à mycobactérie atypique. Le patient 1 a développé une aspergillose pulmonaire chronique nécrosante (APCN) plusieurs mois après le diagnostic d’une infection à Mycobacterium avium. Le patient 2 a développé un aspergillome quelques semaines après le diagnostic d’une infection à Mycobacterium xenopi. L’association de ces deux pathologies pose des problèmes diagnostiques et thérapeutiques qui sont discutés. La survenue d’une pathologie pulmonaire à Aspergillus peut compliquer les infections à mycobactéries atypiques et expliquer une évolution défavorable sous traitement. Nos deux observations suggèrent l’intérêt d’une recherche systématique d’aspergillose pulmonaire au cours du suivi évolutif des infections à mycobactéries atypiques. Atypical mycobacteria and Aspergillus are opportunistic organisms responsible for severe pulmonary diseases whose development is encouraged by the presence of chronic obstructive pulmonary disease (COPD) and related immunosuppression. We report the cases of two patients, both alcoholics with emphysematous COPD, who developed chronic pulmonary aspergillosis following atypical mycobacterial infection. Patient 1 developed chronic necrotising aspergillosis several months after the diagnosis of infection with Mycobacterium avium. Patient 2 developed an aspergilloma several weeks after the diagnosis of infection with Mycobacterium xenopi. The association of these two pathologies presents diagnostic and therapeutic problems that are discussed. The development of Aspergillus pulmonary disease may complicate atypical mycobacterial infections and explain a poor response to treatment. Our two case reports suggest that a systematic search should be made for pulmonary aspergillosis during the follow-up of patients with atypical mycobacterial infection." @default.
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- W32003125 date "2012-01-01" @default.
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- W32003125 title "Aspergillose pulmonaire compliquant une infection à mycobactérie atypique chez deux patients atteints de bronchopneumopathie chronique obstructive" @default.
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- W32003125 doi "https://doi.org/10.1016/j.rmr.2011.07.006" @default.
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