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- W3200319266 endingPage "1217" @default.
- W3200319266 startingPage "1210" @default.
- W3200319266 abstract "When helper T (TH) cell polarization was initially described three decades ago, the TH cell universe grew dramatically. New subsets were described based on their expression of few specific cytokines. Beyond TH1 and TH2 cells, this led to the coining of various TH17 and regulatory (Treg) cell subsets as well as TH22, TH25, follicular helper (TFH), TH3, TH5 and TH9 cells. High-dimensional single-cell analysis revealed that a categorization of TH cells into a single-cytokine-based nomenclature fails to capture the complexity and diversity of TH cells. Similar to the simple nomenclature used to describe innate lymphoid cells (ILCs), we propose that TH cell polarization should be categorized in terms of the help they provide to phagocytes (type 1), to B cells, eosinophils and mast cells (type 2) and to non-immune tissue cells, including the stroma and epithelium (type 3). Studying TH cells based on their helper function and the cells they help, rather than phenotypic features such as individual analyzed cytokines or transcription factors, better captures TH cell plasticity and conversion as well as the breadth of immune responses in vivo." @default.
- W3200319266 created "2021-09-27" @default.
- W3200319266 creator A5001353818 @default.
- W3200319266 creator A5025746046 @default.
- W3200319266 creator A5044855793 @default.
- W3200319266 creator A5044947156 @default.
- W3200319266 creator A5045293467 @default.
- W3200319266 creator A5051595544 @default.
- W3200319266 creator A5067928852 @default.
- W3200319266 creator A5084119660 @default.
- W3200319266 date "2021-09-20" @default.
- W3200319266 modified "2023-10-18" @default.
- W3200319266 title "Repositioning TH cell polarization from single cytokines to complex help" @default.
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