Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200326990> ?p ?o ?g. }
- W3200326990 abstract "Superantigens are unconventional antigens which recognise immune receptors outside their usual recognition sites e.g. complementary determining regions (CDRs), to elicit a response within the target cell. T-cell superantigens crosslink T-cell receptors and MHC Class II molecules on antigen-presenting cells, leading to lymphocyte recruitment, induction of cytokine storms and T-cell anergy or apoptosis among many other effects. B-cell superantigens, on the other hand, bind immunoglobulins on B-cells, affecting opsonisation, IgG-mediated phagocytosis, and driving apoptosis. Here, through a review of the structural basis for recognition of immune receptors by superantigens, we show that their binding interfaces share specific physicochemical characteristics when compared with other protein-protein interaction complexes. Given that antibody-binding superantigens have been exploited extensively in industrial antibody purification, these observations could facilitate further protein engineering to optimize the use of superantigens in this and other areas of biotechnology." @default.
- W3200326990 created "2021-09-27" @default.
- W3200326990 creator A5038527769 @default.
- W3200326990 creator A5051092111 @default.
- W3200326990 creator A5055935319 @default.
- W3200326990 date "2021-09-20" @default.
- W3200326990 modified "2023-09-30" @default.
- W3200326990 title "Superantigen Recognition and Interactions: Functions, Mechanisms and Applications" @default.
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