FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200329507> ?p ?o ?g. }

• W3200329507 endingPage "163" @default.
• W3200329507 startingPage "153" @default.
• W3200329507 abstract "Novel bioactive injectable composites based on biopolymeric hydrogels reinforced with insulin-functionalized silica particles were synthesized. The insulin (INS) was immobilized on the surface of amine-modified silica particles employing covalent attachment by EDC/NHS chemistry and via electrostatic interaction. The resulting formulations were examined for the morphology (SEM), chemical composition (FTIR, XPS) as well as protein content. To facilitate the injectability and support the bone regeneration, developed particles were dispersed in biopolymeric sol composed of collagen, chitosan and lysine-modified hyaluronic acid and crosslinked with genipin. By means of rheological study, the sol-gel in situ transition of obtained systems was verified. It was found in vitro study that MG-63 cells cultured on the developed composites exhibit significantly higher alkaline phosphatase (ALP) activity, compared to the pristine hydrogel. Furthermore, the biomineralization ability in the simulated body fluid (SBF) model was also demonstrated. Our findings suggest that proposed herein novel hydrogel-based composites might be the promising formulation for regeneration of bone defects, especially as a less-cost effective support/alternative for BMP-2 systems." @default.
• W3200329507 created "2021-09-27" @default.
• W3200329507 creator A5041783083 @default.
• W3200329507 creator A5071261352 @default.
• W3200329507 creator A5077715738 @default.
• W3200329507 creator A5086027012 @default.
• W3200329507 date "2022-04-01" @default.
• W3200329507 modified "2023-10-17" @default.
• W3200329507 title "Bioactive injectable composites based on insulin-functionalized silica particles reinforced polymeric hydrogels for potential applications in bone tissue engineering" @default.
• W3200329507 cites W1964161207 @default.
• W3200329507 cites W1970704374 @default.
• W3200329507 cites W1981701289 @default.
• W3200329507 cites W1996809628 @default.
• W3200329507 cites W2001261538 @default.
• W3200329507 cites W2021567011 @default.
• W3200329507 cites W2022199852 @default.
• W3200329507 cites W2055747327 @default.
• W3200329507 cites W2060208108 @default.
• W3200329507 cites W2102300005 @default.
• W3200329507 cites W2128338817 @default.
• W3200329507 cites W2128545518 @default.
• W3200329507 cites W2164623855 @default.
• W3200329507 cites W2300722971 @default.
• W3200329507 cites W2474516624 @default.
• W3200329507 cites W2494789440 @default.
• W3200329507 cites W2514106429 @default.
• W3200329507 cites W2551172807 @default.
• W3200329507 cites W2632796145 @default.
• W3200329507 cites W2687272196 @default.
• W3200329507 cites W2734694702 @default.
• W3200329507 cites W2779999547 @default.
• W3200329507 cites W2793228637 @default.
• W3200329507 cites W2883308547 @default.
• W3200329507 cites W2884999195 @default.
• W3200329507 cites W2890345333 @default.
• W3200329507 cites W2954651563 @default.
• W3200329507 cites W2985539442 @default.
• W3200329507 cites W3007879466 @default.
• W3200329507 cites W3009426164 @default.
• W3200329507 cites W3033228635 @default.
• W3200329507 cites W3067029739 @default.
• W3200329507 cites W3085150136 @default.
• W3200329507 cites W54220445 @default.
• W3200329507 cites W843859016 @default.
• W3200329507 cites W2009950625 @default.
• W3200329507 doi "https://doi.org/10.1016/j.jmst.2021.08.003" @default.
• W3200329507 hasPublicationYear "2022" @default.
• W3200329507 type Work @default.
• W3200329507 sameAs 3200329507 @default.
• W3200329507 citedByCount "11" @default.
• W3200329507 countsByYear W32003295072022 @default.
• W3200329507 countsByYear W32003295072023 @default.
• W3200329507 crossrefType "journal-article" @default.
• W3200329507 hasAuthorship W3200329507A5041783083 @default.
• W3200329507 hasAuthorship W3200329507A5071261352 @default.
• W3200329507 hasAuthorship W3200329507A5077715738 @default.
• W3200329507 hasAuthorship W3200329507A5086027012 @default.
• W3200329507 hasConcept C108586683 @default.
• W3200329507 hasConcept C114874019 @default.
• W3200329507 hasConcept C127413603 @default.
• W3200329507 hasConcept C136229726 @default.
• W3200329507 hasConcept C159985019 @default.
• W3200329507 hasConcept C160160445 @default.
• W3200329507 hasConcept C178790620 @default.
• W3200329507 hasConcept C180577832 @default.
• W3200329507 hasConcept C181199279 @default.
• W3200329507 hasConcept C183586093 @default.
• W3200329507 hasConcept C185592680 @default.
• W3200329507 hasConcept C188027245 @default.
• W3200329507 hasConcept C192562407 @default.
• W3200329507 hasConcept C26771246 @default.
• W3200329507 hasConcept C2777529286 @default.
• W3200329507 hasConcept C2778823387 @default.
• W3200329507 hasConcept C2779732960 @default.
• W3200329507 hasConcept C2781438746 @default.
• W3200329507 hasConcept C42360764 @default.
• W3200329507 hasConcept C49892992 @default.
• W3200329507 hasConcept C54355233 @default.
• W3200329507 hasConcept C71924100 @default.
• W3200329507 hasConcept C86803240 @default.
• W3200329507 hasConceptScore W3200329507C108586683 @default.
• W3200329507 hasConceptScore W3200329507C114874019 @default.
• W3200329507 hasConceptScore W3200329507C127413603 @default.
• W3200329507 hasConceptScore W3200329507C136229726 @default.
• W3200329507 hasConceptScore W3200329507C159985019 @default.
• W3200329507 hasConceptScore W3200329507C160160445 @default.
• W3200329507 hasConceptScore W3200329507C178790620 @default.
• W3200329507 hasConceptScore W3200329507C180577832 @default.
• W3200329507 hasConceptScore W3200329507C181199279 @default.
• W3200329507 hasConceptScore W3200329507C183586093 @default.
• W3200329507 hasConceptScore W3200329507C185592680 @default.
• W3200329507 hasConceptScore W3200329507C188027245 @default.
• W3200329507 hasConceptScore W3200329507C192562407 @default.
• W3200329507 hasConceptScore W3200329507C26771246 @default.
• W3200329507 hasConceptScore W3200329507C2777529286 @default.
• W3200329507 hasConceptScore W3200329507C2778823387 @default.
• W3200329507 hasConceptScore W3200329507C2779732960 @default.
• W3200329507 hasConceptScore W3200329507C2781438746 @default.

• next