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- W3200330566 abstract "Abstract Purpose: Bone metastasis (BM) lesions are always considered to be non-measurable. In this study, we established a method that proved to be measurable the subtypes of BM by in vivo advanced imaging including bone scintigraphy (BS) and single-photon emission computed tomography (SPECT) with 99mTechnetium-methylene diphosphonate (99mTc-MDP) fused computed tomography (CT), combined with skeletal radiography (XR). Methods: One retrospective clinical audit was investigated on lung cancer patients who suffer from BM. The audit includes early static planar, later Whole-body skeleton images and a random sample of 198 patients who were performed on fusion of SPECT/CT scanners. Among them, 108 patients with BM were definite histologic diagnosed with lung cancer and 257 bone lesions were classified. A preclinical precision study developed a procedure of hot spot-based bone imaging screening experimental BM clone by performing anesthesia, intracardiac injection of five human lung cancer cells on the immunodeficient mice, reanimate, in vivo imaging and in vitro experiments (cell culture, histology, karyotype analysis, microarrays, real-time polymerase chain reaction assay (RT-PCR), and immunohistochemistry (IHC)). An osteolytic metastatic clone MDA-MB-231Bo (231Bo) was compared. Irradiation damage was tested. Results: The clinical reports showed the incidence was primarily osteoblastic lesions, followed by mixed lesions and osteolytic. This study does not only confirmed the in vivo advanced imaging could be used to monitor and measure the subtypes of BM from clinical and preclinical data but also have ideal images (including movies), unique cell lines same as homo-sapiens, two markers associated with BM, TMEM100 and CDH1, as well as data from five pairs (BM clones and their parental cells) of lung cancer cells that released into GEO for further research. Ionizing radiation is controlled at its best. Conclusion: The studies have demonstrated that bone lesions of 1mm or larger can be detected in mouse models. Osteolytic lesions were revealed that a flow of metastatic cells out of the destroying cortical bone gap to form a soft tissue tumor. This study and GEO data are applicable to the development of relevant research and treatments." @default.
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- W3200330566 date "2021-01-15" @default.
- W3200330566 modified "2023-10-16" @default.
- W3200330566 title "An Appropriate Method of Measuring Bone Metastatic Subtypes by In Vivo Advanced Imaging from Clinical to Preclinical Study" @default.
- W3200330566 doi "https://doi.org/10.21203/rs.3.rs-145988/v1" @default.
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