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- W3200342071 abstract "Extracellular agonists linked to inositol-1,4,5-trisphosphate (IP3) formation elicit cytosolic Ca2+ oscillations in many cell types, but despite a common signaling pathway, distinct agonist-specific Ca2+ spike patterns are observed. Using qPCR, we show that rat hepatocytes express multiple purinergic P2Y and P2X receptors (R). ADP acting through P2Y1R elicits narrow Ca2+ oscillations, whereas UTP acting through P2Y2R elicits broad Ca2+ oscillations, with composite patterns observed for ATP. P2XRs do not play a role at physiological agonist levels. The discrete Ca2+ signatures reflect differential effects of protein kinase C (PKC), which selectively modifies the falling phase of the Ca2+ spikes. Negative feedback by PKC limits the duration of P2Y1R-induced Ca2+ spikes in a manner that requires extracellular Ca2+. By contrast, P2Y2R is resistant to PKC negative feedback. Thus, the PKC leg of the bifurcated IP3 signaling pathway shapes unique Ca2+ oscillation patterns that allows for distinct cellular responses to different agonists." @default.
- W3200342071 created "2021-09-27" @default.
- W3200342071 creator A5041917605 @default.
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- W3200342071 date "2021-10-01" @default.
- W3200342071 modified "2023-10-18" @default.
- W3200342071 title "Receptor-specific Ca2+ oscillation patterns mediated by differential regulation of P2Y purinergic receptors in rat hepatocytes" @default.
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- W3200342071 doi "https://doi.org/10.1016/j.isci.2021.103139" @default.
- W3200342071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8496176" @default.
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- W3200342071 hasPublicationYear "2021" @default.
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