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- W3200345171 endingPage "1244" @default.
- W3200345171 startingPage "1231" @default.
- W3200345171 abstract "The generation of lymphoid tissues during embryogenesis relies on group 3 innate lymphoid cells (ILC3) displaying lymphoid tissue inducer (LTi) activity and expressing the master transcription factor RORγt. Accordingly, RORγt-deficient mice lack ILC3 and lymphoid structures, including lymph nodes (LN). Whereas T-bet affects differentiation and functions of ILC3 postnatally, the role of T-bet in regulating fetal ILC3 and LN formation remains completely unknown. Using multiple mouse models and single-cell analyses of fetal ILCs and ILC progenitors (ILCP), here we identify a key role for T-bet during embryogenesis and show that its deficiency rescues LN formation in RORγt-deficient mice. Mechanistically, T-bet deletion skews the differentiation fate of fetal ILCs and promotes the accumulation of PLZFhi ILCP expressing central LTi molecules in a RORα-dependent fashion. Our data unveil an unexpected role for T-bet and RORα during embryonic ILC function and highlight that RORγt is crucial in counteracting the suppressive effects of T-bet. Romagnani and colleagues discover an unexpected role for T-bet and RORα during embryonic ILC function and highlight that RORγt is crucial in counteracting the suppressive effects of T-bet." @default.
- W3200345171 created "2021-09-27" @default.
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- W3200345171 date "2021-09-23" @default.
- W3200345171 modified "2023-10-17" @default.
- W3200345171 title "T-bet and RORα control lymph node formation by regulating embryonic innate lymphoid cell differentiation" @default.
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- W3200345171 doi "https://doi.org/10.1038/s41590-021-01029-6" @default.
- W3200345171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34556887" @default.