Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200345739> ?p ?o ?g. }
- W3200345739 abstract "Abstract Defects in the pancreatic β-cell’s secretion system are well-described in Type 2 diabetes (T2D) and include impaired proinsulin processing and a deficit in mature insulin-containing secretory granules; however, the cellular mechanisms underlying these defects and the contribution of hyperglycemia to this process remain poorly understood. Here, we used an in situ fluorescent pulse-chase strategy and proximity labeling-based quantitative proteomics analysis to study proinsulin trafficking and demonstrate a direct link to glucose metabolism via the production of redox intermediates that facilitate proinsulin export from the ER. We show that ER export of proinsulin is delayed in T2D models resulting in decreased insulin granule formation and further demonstrate this process can be regulated by NADPH and reducing equivalent availability. Together, these data highlight a critical role for nutrient metabolism and mitochondrial dysfunction in the maladaptive remodeling of the β-cell’s secretory pathway in the decline of β-cell function in T2D." @default.
- W3200345739 created "2021-09-27" @default.
- W3200345739 creator A5006266328 @default.
- W3200345739 creator A5018569108 @default.
- W3200345739 creator A5023223592 @default.
- W3200345739 creator A5030040129 @default.
- W3200345739 creator A5036616302 @default.
- W3200345739 creator A5053455863 @default.
- W3200345739 creator A5053630640 @default.
- W3200345739 creator A5063514109 @default.
- W3200345739 creator A5066354200 @default.
- W3200345739 creator A5077726771 @default.
- W3200345739 creator A5086590590 @default.
- W3200345739 creator A5090874046 @default.
- W3200345739 date "2021-09-23" @default.
- W3200345739 modified "2023-09-27" @default.
- W3200345739 title "Nutrient metabolism regulates insulin granule formation in the pancreatic islet β-cell via ER redox homeostasis" @default.
- W3200345739 cites W1505761263 @default.
- W3200345739 cites W1604160535 @default.
- W3200345739 cites W173210163 @default.
- W3200345739 cites W1960734071 @default.
- W3200345739 cites W1964975939 @default.
- W3200345739 cites W1966651928 @default.
- W3200345739 cites W1969480413 @default.
- W3200345739 cites W1971413372 @default.
- W3200345739 cites W1979025881 @default.
- W3200345739 cites W1981153918 @default.
- W3200345739 cites W1984262473 @default.
- W3200345739 cites W1987361428 @default.
- W3200345739 cites W2023590295 @default.
- W3200345739 cites W2023949937 @default.
- W3200345739 cites W2034792944 @default.
- W3200345739 cites W2036741271 @default.
- W3200345739 cites W2037857580 @default.
- W3200345739 cites W2043681654 @default.
- W3200345739 cites W2048456744 @default.
- W3200345739 cites W2057141116 @default.
- W3200345739 cites W2060216777 @default.
- W3200345739 cites W2074549465 @default.
- W3200345739 cites W2082419614 @default.
- W3200345739 cites W2088160164 @default.
- W3200345739 cites W2100981646 @default.
- W3200345739 cites W2112990256 @default.
- W3200345739 cites W2117812417 @default.
- W3200345739 cites W2119902047 @default.
- W3200345739 cites W2121769863 @default.
- W3200345739 cites W2123767112 @default.
- W3200345739 cites W2124706352 @default.
- W3200345739 cites W2124971376 @default.
- W3200345739 cites W2125713853 @default.
- W3200345739 cites W2142418958 @default.
- W3200345739 cites W2142536100 @default.
- W3200345739 cites W2150202137 @default.
- W3200345739 cites W2153134360 @default.
- W3200345739 cites W2159586070 @default.
- W3200345739 cites W2162711454 @default.
- W3200345739 cites W2172099021 @default.
- W3200345739 cites W2198859596 @default.
- W3200345739 cites W2295351013 @default.
- W3200345739 cites W2579734568 @default.
- W3200345739 cites W2583760957 @default.
- W3200345739 cites W2589123864 @default.
- W3200345739 cites W2611238787 @default.
- W3200345739 cites W2753008210 @default.
- W3200345739 cites W2770116234 @default.
- W3200345739 cites W2772607655 @default.
- W3200345739 cites W2780317778 @default.
- W3200345739 cites W2785561867 @default.
- W3200345739 cites W2793821186 @default.
- W3200345739 cites W2811387400 @default.
- W3200345739 cites W2899760200 @default.
- W3200345739 cites W2913854962 @default.
- W3200345739 cites W2948594834 @default.
- W3200345739 cites W2949126444 @default.
- W3200345739 cites W2952797006 @default.
- W3200345739 cites W2953056615 @default.
- W3200345739 cites W2953194011 @default.
- W3200345739 cites W2963272561 @default.
- W3200345739 cites W2963845809 @default.
- W3200345739 cites W3011224064 @default.
- W3200345739 cites W3012194254 @default.
- W3200345739 cites W3021575031 @default.
- W3200345739 cites W3030239762 @default.
- W3200345739 cites W3164492643 @default.
- W3200345739 cites W3174565508 @default.
- W3200345739 cites W3182939360 @default.
- W3200345739 doi "https://doi.org/10.1101/2021.09.22.461417" @default.
- W3200345739 hasPublicationYear "2021" @default.
- W3200345739 type Work @default.
- W3200345739 sameAs 3200345739 @default.
- W3200345739 citedByCount "5" @default.
- W3200345739 countsByYear W32003457392021 @default.
- W3200345739 countsByYear W32003457392022 @default.
- W3200345739 crossrefType "posted-content" @default.
- W3200345739 hasAuthorship W3200345739A5006266328 @default.
- W3200345739 hasAuthorship W3200345739A5018569108 @default.
- W3200345739 hasAuthorship W3200345739A5023223592 @default.
- W3200345739 hasAuthorship W3200345739A5030040129 @default.
- W3200345739 hasAuthorship W3200345739A5036616302 @default.
- W3200345739 hasAuthorship W3200345739A5053455863 @default.