FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200349664> ?p ?o ?g. }

• W3200349664 endingPage "ii58" @default.
• W3200349664 startingPage "ii58" @default.
• W3200349664 abstract "Abstract BACKGROUND Meningiomas are the most common group of adult central nervous system primary tumor. The major known predictors for meningioma recurrence are extent of surgical resection and histological grade. Although grading system is the actual standard for risk classification, there are several exceptions in the clinical behavior. Recent studies have shown that meningiomas can express PD-L1, a known therapeutic target for checkpoint inhibitors. Tumor microenvironment and hormonal setting are known to influence the immune system response. The only standard therapeutic strategies nowadays are surgery and radiotherapy. Meningiomas microenvironment needs to be further studied looking for new therapeutic targets. New prognostic tools combining histological and radiological features (RF) are needed to better address the treatment strategy. ELIGIBILITY CRITERIA Patients diagnosed with meningioma who underwent surgery at the Department of Neurosurgery of the IRCCS Ospedale Policlinico San Martino of Genoa from 1998. - Availability of magnetic resonance imaging (MRI) at diagnosis. - Availability of histological samples. OBJECTIVES Identification and prevalence of immune-related biomarkers and their correlation with morphological and hormonal features. - Survival analyses in the study population and according to the different characteristics analyzed. - The identification of specific clinical, histological and RF of meningiomas and their inclusion in a prognostic signature. STUDY DESIGN This is a retrospective-prospective monocentric study designed to analyze clinical, radiological and histological features of meningioma patients. - Clinical data will be collected from the electronic patient records. - Analyses will be conducted on a cohort of patients enriched with higher grade meningioma to balance the proportion between high and low grade histologies. - Histological specimen will be blindly reviewed and reclassified according to histological type, morphological features and WHO 2016 criteria. - The MRI features will be analyzed at diagnosis. STUDY ANALYSIS We retrospectively enrolled 50 patients with available radiological, histological and clinical data.- All histopathological specimens will be examined with slides obtained from material fixed in 10% neutral buffered formalin, included in kerosene, sectioned at 3 µm and stained with hematoxylin-eosin. - We will look for the presence of estrogens and progesterone receptors. - Concerning immune-related biomarkers we will further assess PD-L1 positivity (cut-off: positive 1%, negative &lt;1%), MSI status and the inflammatory infiltrate with immunohistochemistry, in particular TILs (CD45, CD3, CD4, CD8, FOXP3, CTLA4), B cell (CD20), TAM (CD68). - All histological and radiological data will be analyzed and correlated with the clinical characteristics of meningioma patients and their outcomes." @default.
• W3200349664 created "2021-09-27" @default.
• W3200349664 creator A5007975502 @default.
• W3200349664 creator A5010356903 @default.
• W3200349664 creator A5027134888 @default.
• W3200349664 creator A5031191206 @default.
• W3200349664 creator A5054986330 @default.
• W3200349664 creator A5060876128 @default.
• W3200349664 creator A5062177002 @default.
• W3200349664 creator A5078881408 @default.
• W3200349664 creator A5081227059 @default.
• W3200349664 creator A5089895444 @default.
• W3200349664 date "2021-09-01" @default.
• W3200349664 modified "2023-09-24" @default.
• W3200349664 title "P16.13 MenImmune: Evaluation of immune-related and prognostic biomarkers in meningioma" @default.
• W3200349664 doi "https://doi.org/10.1093/neuonc/noab180.203" @default.
• W3200349664 hasPublicationYear "2021" @default.
• W3200349664 type Work @default.
• W3200349664 sameAs 3200349664 @default.
• W3200349664 citedByCount "0" @default.
• W3200349664 crossrefType "journal-article" @default.
• W3200349664 hasAuthorship W3200349664A5007975502 @default.
• W3200349664 hasAuthorship W3200349664A5010356903 @default.
• W3200349664 hasAuthorship W3200349664A5027134888 @default.
• W3200349664 hasAuthorship W3200349664A5031191206 @default.
• W3200349664 hasAuthorship W3200349664A5054986330 @default.
• W3200349664 hasAuthorship W3200349664A5060876128 @default.
• W3200349664 hasAuthorship W3200349664A5062177002 @default.
• W3200349664 hasAuthorship W3200349664A5078881408 @default.
• W3200349664 hasAuthorship W3200349664A5081227059 @default.
• W3200349664 hasAuthorship W3200349664A5089895444 @default.
• W3200349664 hasBestOaLocation W32003496641 @default.
• W3200349664 hasConcept C126322002 @default.
• W3200349664 hasConcept C126838900 @default.
• W3200349664 hasConcept C127413603 @default.
• W3200349664 hasConcept C12770488 @default.
• W3200349664 hasConcept C143409427 @default.
• W3200349664 hasConcept C143998085 @default.
• W3200349664 hasConcept C147176958 @default.
• W3200349664 hasConcept C188816634 @default.
• W3200349664 hasConcept C190892606 @default.
• W3200349664 hasConcept C2777286243 @default.
• W3200349664 hasConcept C2779160599 @default.
• W3200349664 hasConcept C2908647359 @default.
• W3200349664 hasConcept C509974204 @default.
• W3200349664 hasConcept C71924100 @default.
• W3200349664 hasConcept C72563966 @default.
• W3200349664 hasConcept C99454951 @default.
• W3200349664 hasConceptScore W3200349664C126322002 @default.
• W3200349664 hasConceptScore W3200349664C126838900 @default.
• W3200349664 hasConceptScore W3200349664C127413603 @default.
• W3200349664 hasConceptScore W3200349664C12770488 @default.
• W3200349664 hasConceptScore W3200349664C143409427 @default.
• W3200349664 hasConceptScore W3200349664C143998085 @default.
• W3200349664 hasConceptScore W3200349664C147176958 @default.
• W3200349664 hasConceptScore W3200349664C188816634 @default.
• W3200349664 hasConceptScore W3200349664C190892606 @default.
• W3200349664 hasConceptScore W3200349664C2777286243 @default.
• W3200349664 hasConceptScore W3200349664C2779160599 @default.
• W3200349664 hasConceptScore W3200349664C2908647359 @default.
• W3200349664 hasConceptScore W3200349664C509974204 @default.
• W3200349664 hasConceptScore W3200349664C71924100 @default.
• W3200349664 hasConceptScore W3200349664C72563966 @default.
• W3200349664 hasConceptScore W3200349664C99454951 @default.
• W3200349664 hasIssue "Supplement_2" @default.
• W3200349664 hasLocation W32003496641 @default.
• W3200349664 hasOpenAccess W3200349664 @default.
• W3200349664 hasPrimaryLocation W32003496641 @default.
• W3200349664 hasRelatedWork W2013006019 @default.
• W3200349664 hasRelatedWork W2022609357 @default.
• W3200349664 hasRelatedWork W2036714644 @default.
• W3200349664 hasRelatedWork W2073295024 @default.
• W3200349664 hasRelatedWork W2092349519 @default.
• W3200349664 hasRelatedWork W2321170868 @default.
• W3200349664 hasRelatedWork W2768104750 @default.
• W3200349664 hasRelatedWork W3093813998 @default.
• W3200349664 hasRelatedWork W4210724732 @default.
• W3200349664 hasRelatedWork W4246718148 @default.
• W3200349664 hasVolume "23" @default.
• W3200349664 isParatext "false" @default.
• W3200349664 isRetracted "false" @default.
• W3200349664 magId "3200349664" @default.
• W3200349664 workType "article" @default.