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• W3200414863 abstract "Magnetic nanoparticles (MNP) are widely used in nanomedicine for diagnostic and therapeutic applications due to their unique magnetic relaxation properties. A prominent application is magnetic fluid hyperthermia (MFH), which describes use of therapeutic heat generated by magnetic excitation and relaxation processes of MNP in an alternating magnetic field (AMF) enabling tumor-confined cancer therapy. The heating efficiency of MNP depends on their size and magnetic properties as well as on the parameters of the AMF. The high degree of interdependency between these parameters makes the description of MFH very complex. The two established MNP heating theories, linear response theory (LRT) and Stoner–Wohlfarth model based theory (SWMBT), lack a comprehensive implementation of MNP dynamic relaxation processes. Advanced nonequilibrium magnetic relaxation simulations, however, provide an understanding of the fundamentals of their magnetic relaxation processes in AMF. They offer an appropriate model system for studying the interdependence of the above-mentioned parameters and are, therefore, a powerful tool predicting MNP heating behavior. Here, the implementation of MNP relaxation physics into Monte Carlo (MC-) simulations is shown in detail and the heating efficiency is determined in dependency of MNP magnetic size and anisotropy energy constant, as well as the AFM parameters. The results are compared to those determined from LRT and SWMBT and it is concluded that MC-simulations can be generally applied to predict MNP heating with superior results: Specifically, MNP particle heating increases with increasing the AFM, and a specific particle size can be predicted that maximizes the heating efficiency, while the dependency on magnetic anisotropy remains a topic of ongoing discussion. On a wider scope, the benefit and experimental applicability of MC-simulations in the biosensing and magnetic particle imaging research are briefly discussed, demonstrating the versatility of magnetic relaxation simulations." @default.
• W3200414863 created "2021-09-27" @default.
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• W3200414863 date "2021-08-30" @default.
• W3200414863 modified "2023-09-25" @default.
• W3200414863 title "Magnetic Nanoparticle Relaxation in Biomedical Application" @default.
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• W3200414863 doi "https://doi.org/10.1002/9781119754725.ch15" @default.
• W3200414863 hasPublicationYear "2021" @default.
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