FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200416367> ?p ?o ?g. }

• W3200416367 abstract "There is great interest in understanding the cellular mechanisms controlling autophagy, a tightly regulated catabolic and stress-response pathway. Prior work has uncovered links between autophagy and the Golgi reassembly stacking protein of 55 kDa (GRASP55), but their precise interrelationship remains unclear. Intriguingly, both autophagy and GRASP55 have been functionally and spatially linked to the endoplasmic reticulum (ER)---Golgi interface, broaching this compartment as a site where GRASP55 and autophagy may intersect. Here, we uncover that loss of GRASP55 enhances LC3 puncta formation, indicating that GRASP55 restricts autophagosome formation. Additionally, using proximity-dependent biotinylation, we identify a GRASP55 proximal interactome highly associated with the ER-Golgi interface. Both nutrient starvation and loss of GRASP55 are associated with coalescence of early secretory pathway markers. In light of these findings, we propose that GRASP55 regulates spatial organization of the ER-Golgi interface, which suppresses early autophagosome formation." @default.
• W3200416367 created "2021-09-27" @default.
• W3200416367 creator A5001716925 @default.
• W3200416367 creator A5009044856 @default.
• W3200416367 creator A5021367279 @default.
• W3200416367 creator A5033367990 @default.
• W3200416367 creator A5054953479 @default.
• W3200416367 creator A5061420018 @default.
• W3200416367 creator A5081015261 @default.
• W3200416367 date "2021-10-12" @default.
• W3200416367 modified "2023-10-14" @default.
• W3200416367 title "GRASP55 restricts early-stage autophagy and regulates spatial organization of the early secretory network" @default.
• W3200416367 cites W1523693806 @default.
• W3200416367 cites W1854727002 @default.
• W3200416367 cites W1942767863 @default.
• W3200416367 cites W1965661521 @default.
• W3200416367 cites W1975981696 @default.
• W3200416367 cites W1977709885 @default.
• W3200416367 cites W1977767269 @default.
• W3200416367 cites W1987035178 @default.
• W3200416367 cites W1987517959 @default.
• W3200416367 cites W1988110756 @default.
• W3200416367 cites W1990975852 @default.
• W3200416367 cites W2012651561 @default.
• W3200416367 cites W2020044636 @default.
• W3200416367 cites W2030749742 @default.
• W3200416367 cites W2034145518 @default.
• W3200416367 cites W2041063545 @default.
• W3200416367 cites W2043291430 @default.
• W3200416367 cites W2054783408 @default.
• W3200416367 cites W2082278337 @default.
• W3200416367 cites W2082372749 @default.
• W3200416367 cites W2088060011 @default.
• W3200416367 cites W2095944856 @default.
• W3200416367 cites W2097570183 @default.
• W3200416367 cites W2103017472 @default.
• W3200416367 cites W2105707485 @default.
• W3200416367 cites W2106693434 @default.
• W3200416367 cites W2109070574 @default.
• W3200416367 cites W2125599080 @default.
• W3200416367 cites W2127767424 @default.
• W3200416367 cites W2128018620 @default.
• W3200416367 cites W2132440898 @default.
• W3200416367 cites W2143896579 @default.
• W3200416367 cites W2157096314 @default.
• W3200416367 cites W2161895799 @default.
• W3200416367 cites W2166443964 @default.
• W3200416367 cites W2536606258 @default.
• W3200416367 cites W2567789553 @default.
• W3200416367 cites W2578320976 @default.
• W3200416367 cites W2743254891 @default.
• W3200416367 cites W2795845448 @default.
• W3200416367 cites W2799285454 @default.
• W3200416367 cites W2900044275 @default.
• W3200416367 cites W2900569176 @default.
• W3200416367 cites W2917858269 @default.
• W3200416367 cites W2929997038 @default.
• W3200416367 cites W2952034853 @default.
• W3200416367 cites W2998731501 @default.
• W3200416367 cites W3112600195 @default.
• W3200416367 cites W3136918052 @default.
• W3200416367 doi "https://doi.org/10.1242/bio.058736" @default.
• W3200416367 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8524720" @default.
• W3200416367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34533192" @default.
• W3200416367 hasPublicationYear "2021" @default.
• W3200416367 type Work @default.
• W3200416367 sameAs 3200416367 @default.
• W3200416367 citedByCount "2" @default.
• W3200416367 countsByYear W32004163672022 @default.
• W3200416367 countsByYear W32004163672023 @default.
• W3200416367 crossrefType "journal-article" @default.
• W3200416367 hasAuthorship W3200416367A5001716925 @default.
• W3200416367 hasAuthorship W3200416367A5009044856 @default.
• W3200416367 hasAuthorship W3200416367A5021367279 @default.
• W3200416367 hasAuthorship W3200416367A5033367990 @default.
• W3200416367 hasAuthorship W3200416367A5054953479 @default.
• W3200416367 hasAuthorship W3200416367A5061420018 @default.
• W3200416367 hasAuthorship W3200416367A5081015261 @default.
• W3200416367 hasBestOaLocation W32004163671 @default.
• W3200416367 hasConcept C104317684 @default.
• W3200416367 hasConcept C119062480 @default.
• W3200416367 hasConcept C139447449 @default.
• W3200416367 hasConcept C158617107 @default.
• W3200416367 hasConcept C168296220 @default.
• W3200416367 hasConcept C190283241 @default.
• W3200416367 hasConcept C203522944 @default.
• W3200416367 hasConcept C2780042272 @default.
• W3200416367 hasConcept C54355233 @default.
• W3200416367 hasConcept C6492254 @default.
• W3200416367 hasConcept C86803240 @default.
• W3200416367 hasConcept C95444343 @default.
• W3200416367 hasConcept C9760119 @default.
• W3200416367 hasConceptScore W3200416367C104317684 @default.
• W3200416367 hasConceptScore W3200416367C119062480 @default.
• W3200416367 hasConceptScore W3200416367C139447449 @default.
• W3200416367 hasConceptScore W3200416367C158617107 @default.
• W3200416367 hasConceptScore W3200416367C168296220 @default.
• W3200416367 hasConceptScore W3200416367C190283241 @default.
• W3200416367 hasConceptScore W3200416367C203522944 @default.
• W3200416367 hasConceptScore W3200416367C2780042272 @default.

• next