FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3200416563> ?p ?o ?g. }

• W3200416563 abstract "Abstract Apoptosis is a strictly coordinated process to eliminate superfluous or damaged cells, and its deregulation leads to birth defects and various human diseases. The regulatory mechanism underlying apoptosis still remains incompletely understood. To identify novel components in apoptosis, we carry out a modifier screen and find that the Hh pathway aggravates Hid-induced apoptosis. In addition, we reveal that the Hh pathway triggers apoptosis through its transcriptional target gene rdx , which encodes an E3 ubiquitin ligase. Rdx physically binds Diap1 to promote its K63-linked polyubiquitination, culminating in attenuating Diap1−Dronc interaction without affecting Diap1 stability. Taken together, our findings unexpectedly uncover the oncogenic Hh pathway is able to promote apoptosis through Ci-Rdx-Diap1 module, raising a concern to choose Hh pathway inhibitors as anti-tumor drugs." @default.
• W3200416563 created "2021-09-27" @default.
• W3200416563 creator A5000639089 @default.
• W3200416563 creator A5009198510 @default.
• W3200416563 creator A5011689931 @default.
• W3200416563 creator A5022844051 @default.
• W3200416563 creator A5048826252 @default.
• W3200416563 creator A5067039459 @default.
• W3200416563 date "2021-09-24" @default.
• W3200416563 modified "2023-10-10" @default.
• W3200416563 title "The Hh pathway promotes cell apoptosis through Ci-Rdx-Diap1 axis" @default.
• W3200416563 cites W1615043005 @default.
• W3200416563 cites W1973892237 @default.
• W3200416563 cites W1975711179 @default.
• W3200416563 cites W1977453630 @default.
• W3200416563 cites W1981286174 @default.
• W3200416563 cites W1982124131 @default.
• W3200416563 cites W1990394716 @default.
• W3200416563 cites W1993550226 @default.
• W3200416563 cites W1994847090 @default.
• W3200416563 cites W2000999513 @default.
• W3200416563 cites W2003983038 @default.
• W3200416563 cites W2015781939 @default.
• W3200416563 cites W2017524293 @default.
• W3200416563 cites W2024534024 @default.
• W3200416563 cites W2027151805 @default.
• W3200416563 cites W2027986342 @default.
• W3200416563 cites W2028942472 @default.
• W3200416563 cites W2040930127 @default.
• W3200416563 cites W2050943298 @default.
• W3200416563 cites W2074654296 @default.
• W3200416563 cites W2077494922 @default.
• W3200416563 cites W2082970676 @default.
• W3200416563 cites W2084144301 @default.
• W3200416563 cites W2085197940 @default.
• W3200416563 cites W2087731279 @default.
• W3200416563 cites W2088342479 @default.
• W3200416563 cites W2088557523 @default.
• W3200416563 cites W2100067355 @default.
• W3200416563 cites W2104467548 @default.
• W3200416563 cites W2107319240 @default.
• W3200416563 cites W2109023063 @default.
• W3200416563 cites W2117692326 @default.
• W3200416563 cites W2121527066 @default.
• W3200416563 cites W2125255426 @default.
• W3200416563 cites W2144217701 @default.
• W3200416563 cites W2146838968 @default.
• W3200416563 cites W2147917253 @default.
• W3200416563 cites W2152266226 @default.
• W3200416563 cites W2172225137 @default.
• W3200416563 cites W2346363069 @default.
• W3200416563 cites W2411249987 @default.
• W3200416563 cites W2609489748 @default.
• W3200416563 cites W2745446494 @default.
• W3200416563 cites W2751318448 @default.
• W3200416563 cites W2794222046 @default.
• W3200416563 cites W2912446792 @default.
• W3200416563 cites W2976163884 @default.
• W3200416563 cites W2981449615 @default.
• W3200416563 cites W3004902791 @default.
• W3200416563 cites W3032436317 @default.
• W3200416563 cites W3033278232 @default.
• W3200416563 cites W3093814968 @default.
• W3200416563 cites W3135558392 @default.
• W3200416563 cites W3145072879 @default.
• W3200416563 cites W4210757594 @default.
• W3200416563 doi "https://doi.org/10.1038/s41420-021-00653-3" @default.
• W3200416563 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8463586" @default.
• W3200416563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34561426" @default.
• W3200416563 hasPublicationYear "2021" @default.
• W3200416563 type Work @default.
• W3200416563 sameAs 3200416563 @default.
• W3200416563 citedByCount "0" @default.
• W3200416563 crossrefType "journal-article" @default.
• W3200416563 hasAuthorship W3200416563A5000639089 @default.
• W3200416563 hasAuthorship W3200416563A5009198510 @default.
• W3200416563 hasAuthorship W3200416563A5011689931 @default.
• W3200416563 hasAuthorship W3200416563A5022844051 @default.
• W3200416563 hasAuthorship W3200416563A5048826252 @default.
• W3200416563 hasAuthorship W3200416563A5067039459 @default.
• W3200416563 hasBestOaLocation W32004165631 @default.
• W3200416563 hasConcept C104317684 @default.
• W3200416563 hasConcept C134459356 @default.
• W3200416563 hasConcept C190283241 @default.
• W3200416563 hasConcept C25602115 @default.
• W3200416563 hasConcept C2777408456 @default.
• W3200416563 hasConcept C31573885 @default.
• W3200416563 hasConcept C502942594 @default.
• W3200416563 hasConcept C54355233 @default.
• W3200416563 hasConcept C86803240 @default.
• W3200416563 hasConcept C95444343 @default.
• W3200416563 hasConceptScore W3200416563C104317684 @default.
• W3200416563 hasConceptScore W3200416563C134459356 @default.
• W3200416563 hasConceptScore W3200416563C190283241 @default.
• W3200416563 hasConceptScore W3200416563C25602115 @default.
• W3200416563 hasConceptScore W3200416563C2777408456 @default.
• W3200416563 hasConceptScore W3200416563C31573885 @default.
• W3200416563 hasConceptScore W3200416563C502942594 @default.
• W3200416563 hasConceptScore W3200416563C54355233 @default.
• W3200416563 hasConceptScore W3200416563C86803240 @default.

• next