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- W3200422785 abstract "Amyloid fibrillization is an exceedingly complex process in which incoming peptide chains bind to the fibril while concertedly folding. The coupling between folding and binding is not fully understood. We explore the molecular pathways of association of Aβ40 monomers to fibril tips by combining time-resolved in situ scanning probe microscopy with molecular modeling. The comparison between experimental and simulation results shows that a complex supported by nonnative contacts is present in the equilibrium structure of the fibril tip and impedes fibril growth in a supersaturated solution. The unraveling of this frustrated state determines the rate of fibril growth. The kinetics of growth of freshly cut fibrils, in which the bulk fibril structure persists at the tip, complemented by molecular simulations, indicate that this frustrated complex comprises three or four monomers in nonnative conformations and likely is contained on the top of a single stack of peptide chains in the fibril structure. This pathway of fibril growth strongly deviates from the common view that the conformational transformation of each captured peptide chain is templated by the previously arrived peptide. The insights into the ensemble structure of the frustrated complex may guide the search for suppressors of Aβ fibrillization. The uncovered dynamics of coupled structuring and assembly during fibril growth are more complex than during the folding of most globular proteins, as they involve the collective motions of several peptide chains that are not guided by a funneled energy landscape." @default.
- W3200422785 created "2021-09-27" @default.
- W3200422785 creator A5030946880 @default.
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- W3200422785 date "2021-09-13" @default.
- W3200422785 modified "2023-10-01" @default.
- W3200422785 title "Frustrated peptide chains at the fibril tip control the kinetics of growth of amyloid-β fibrils" @default.
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- W3200422785 doi "https://doi.org/10.1073/pnas.2110995118" @default.
- W3200422785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8463807" @default.
- W3200422785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34518234" @default.
- W3200422785 hasPublicationYear "2021" @default.