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- W3200423119 abstract "Abstract Understanding the neuronal basis of epileptiform activity is a major challenge in neurology. Interictal epileptiform discharges are associated with fast ripples (FRs, >200 Hz) in the local field potential (LFP) and are a promising marker of the epileptogenic zone. Here, by using a novel hybrid macro-micro depth electrode, combining classic depth recording of LFP and two or three tetrodes enabling up to 15 neurons in local circuits to be recorded simultaneously, we have characterized neuronal responses to FRs on the same hybrid and other electrodes targeting other brain regions. While FRs were associated with increased neuronal activity in local circuits only, they were followed by inhibition in large-scale networks. Neuronal responses to FRs were homogeneous in local networks but differed across brain areas. Similarly, post-FR inhibition varied across recording locations and subjects and was shorter than typical inter-FR intervals, suggesting that this inhibition is a fundamental refractory process for the networks. These findings demonstrate that FRs engage local and global networks and point to network features that pave the way for new diagnostic and therapeutic strategies." @default.
- W3200423119 created "2021-09-27" @default.
- W3200423119 creator A5000314659 @default.
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- W3200423119 creator A5081783191 @default.
- W3200423119 date "2021-09-11" @default.
- W3200423119 modified "2023-09-30" @default.
- W3200423119 title "Local neuronal excitation and global inhibition during epileptic fast ripples in humans" @default.
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- W3200423119 doi "https://doi.org/10.1101/2021.09.09.459695" @default.
- W3200423119 hasPublicationYear "2021" @default.
- W3200423119 type Work @default.