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• W3200428560 abstract "rf1 is a member of the CNC-bZIP (Cap’n’Collar basic regionleucine zipper) group of transcription factors. Four coremembersofthisfamilyhavebeenidentified,i.e.,NF-E2p45,Nrf1,Nrf2, and Nrf3, along with the two more distantly related mem-bers Bach1 and Bach2 (1, 2). Upon stimulation, the CNC-bZIPfactors heterodimerize in the nucleus with small Maf (sMaf) pro-teins (i.e., MafF, MafK, or MafG) before binding to antioxidantresponse element (ARE)/electrophile response element (EpRE)(TGA[G/C]NNNGC) sequences in the promoters of target genes,many of which exert cytoprotective functions. In addition, sMafproteins can form homodimers that bind to a palindromic ex-tended ARE sequence, called a Maf recognition element (MARE)(TGCTGA[G/C]TCAGCA), and in so doing repress genes in-volved in cell differentiation and organization, such as those forrhodopsin and crystallin (3).It has previously been shown that each CNC-bZIP factor reg-ulates a different set of genes, despite the fact that their consensusbinding sequences are similar. While NF-E2 p45 and Nrf3 aresubjecttotissue-specificexpression,inhematopoieticcelllineagesand placenta, respectively (4–6), Nrf1 and Nrf2 are essentially ex-pressed ubiquitously (7). Importantly, it has been speculated thatNrf1 and Nrf2 may exhibit combinational or competitive func-tions, but details of the basis for their distinct activities have yet tobe established (7, 8). Furthermore, while full-length Nrf1 transac-tivates ARE-driven gene expression, several short Nrf1 isoformsexist that have been reported to repress ARE-driven genes (9–11),and this may account for some of the differences observed be-tween Nrf1 and Nrf2.Analyses of gene knockout (KO) mouse lines have providedinvaluable information about the physiological function of CNC-bZIP factors. We and other laboratories have knocked out all ofthe CNC-bZIP factors, and the phenotypes of the resulting micehave been described (12). Among the knockout mouse lines, onlyNrf1-null mice exhibit embryonic lethality. The majority ofNF-E2 p45 knockout mice die because of bleeding during theneonatal period, whereas Nrf2- and Nrf3-null mice develop nor-mally. Nrf1 deficiency results in hepatocyte dysfunction and im-pairment of early hematopoietic development, leading to death atembryonic day 13.5 (E13.5). Importantly, a similar phenotype isobserved in the" @default.
• W3200428560 created "2021-09-27" @default.
• W3200428560 creator A5009095158 @default.
• W3200428560 date "2014-09-05" @default.
• W3200428560 modified "2023-09-26" @default.
• W3200428560 title "(4T09p-05)Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes." @default.
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